经肠镜右半结肠单次喷洒益生菌混悬液对腹泻型肠易激综合征的疗效及安全性

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Abstract Objective To explore the influence of bifid triple viable introduced into the right colon combined with oral pivavironium by enteroscopy on the curative effect, intestinal microflora and inflammatory factors in patients with diarrhea predominant irritable bowel syndrome. Methods Sixty patients with IBS-D who were treated in our hospital between January 2017 to March 2018 were randomly divided into the control group (pibebronium bromide), observation group A (pinaverium bromide + total bifid triple viable 1.6×10⁸ CFU) ,and observation group B (pinaverium bromide + total bifid triple viable 1.6×10⁹ CFU) , with 20 cases in each group. The course of treatment was 4 weeks. The efficacy, intestinal flora before and after treatment and serum IL-10, IL-18 and TNF-a levels were compared between the three groups. Results The curative effect of group B was higher than that of control group (90.0% vs 55.0%, P＜0.05). After 4 weeks of withdrawal, the recurrence rate of group B was significantly lower than that of control group and observation group A, and the difference was statistically significant (respectively). (Lactic acid bacteria, bifidobacteria and bacteroides were significantly increased in group A and group B after treatment (P＜0.05), while E. coli and E. faecalis were significantly lower after treatment (P＜0.05). In these three groups, the intestinal flora in group B were most obviously improved (P＜0.05). After 4 weeks of treatment, the serum levels of IL-18 and TNF-a in group B were significantly lower than those in the control group and group A (P＜0.05), while the serum IL-10 levels were significantly higher than those in the control group (P＜0.05). None of the three groups experienced significant adverse reactions during the treatment. Conclusions The single spraying of bifidobacterium triple viable cell suspension (1.6×10⁹ CFU total) in the right colon combined with oral pinaverium bromide can be used to treat IBS-D effectively and reduce the recurrence rate. The mechanism may be related to improvement of the patients’ intestinal flora and immune function.

Key words： diarrhea-predominant irritable bowel syndrome probiotics enteroscopy efficacy intestinal flora immune function

Received: 24 August 2018

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LIU Qian,PAN Qi. Influence of probiotics introduced into the right colon by enteroscopy on the curative effect, intestinal microflora and inflammatory factors in patients with diarrhea predominant irritable bowel syndrome[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2019, 30(4): 329-333.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2019/V30/I4/329

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