Hec1在膀胱癌组织中的表达及其与临床病理因素和预后的关系

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Abstract Objective To investigate the expression of highly expressed protien in cancer (Hec1) in human bladder cancer and its relationship with clinicopathological factors and prognosis.Methods Immunohistochemistry and Western blot were used to detect the expression of Hec1 in 105 cases of surgically resected human bladder cancer and 20 para-carcinoma normal bladder histopathological specimens. Clinical TNM stage Ⅰ included 31 cases of metastasis and 34 cases without lymph node metastasis. Tumor diameter was 2 cm or less in 49 patients, and 2-5 cm in 35 cases. Twenty-three cases were in stage Ⅱ and 51 cases in stages Ⅲ+Ⅳ. There were 71 cases with lymph node metastasis, and tumor diameter was above 5 cm in 21 patients. The relationship between Hec1, clinicopathological factors and 5-year survival was analyzed by Prism6.0. The Cox proportional hazard model was used to analyze the independent prognostic factors of bladder cancer.Results Hec1 was significantly higher in human bladder cancer than that in para-cancer normal tissue (P<0.01). Hec1 was not significantly correlated with age, the histological type or tumor size(P values were 0.25, 0.17 and 0.26, respectively). However, the level of Hec1 increased with the clinical staging (P=0.042) and lymph node metastasis (P=0.033). The survival rate of Caveolin-1 in bladder cancer patients was lower than that of Hec1 patients (P=0.025). Lymph node metastasis, TNM stage and Hec1 were independent prognostic factors for bladder cancer.Conclusions Hec1 may play the role of a tumor stimulating factor and can facilitate clinical diagnosis, treatment and prognosis.

Key words： bladder carcinoma Hec1 pathology immunohistochemistry

Received: 28 January 2019

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2019/V30/I7/560

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