急性脑梗死患者静脉溶栓后早期神经功能恶化的危险因素

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Abstract Objective To investigate the risk factors for early neurological deterioration after intravenous thrombolysis in patients with acute cerebral infarction.Methods Patients with acute cerebral infarction were selected, who were treated with alteplase thrombolytic therapy within 4.5 h of the onset in our hospital between January 2014 and January 2019. These patients were divided into the early neurological deterioration group and the non-deterioration group according to the occurrence of early neurological deterioration. Demographics, clinical data, and laboratory test indicators were compared between the two groups. The risks factors for early neurological deterioration after intravenous thrombolysis in patients with acute cerebral infarction were analyzed by using multivariate logistic regression analysis.Results A total of 108 patients with acute cerebral infarction were included in the study, 19 of whom were in the early neurological deterioration group. The age, body weight, proportion of atrial fibrillation, baseline NIHSS score, proportion of major vessel narrow or occlusion, white blood cell counts, and levels of fibrinogen in the early neurological deterioration group were significantly above those in the non-deterioration group. Multivariate logistic regression analysis showed that age(OR=3.285; 95%CI:2.023-5.682; P=0.028),body weight(OR=2.679; 95%CI:1.690-6.287; P=0.039), atrial fibrillation(OR=2.551; 95%CI:1.980-4.235; P=0.027), baseline NIHSS score(OR=3.627; 95%CI:6.267-13.331; P=0.018), and levels of fibrinogen(OR=2.016; 95%CI:4.650-7.823; P=0.031) were significantly correlated with early neurological deterioration after intravenous thrombolysis in patients with acute cerebral infarction.Conclusions The incidence of early neurological deterioration after intravenous thrombolysis in patients with acute cerebral infarction is relatively high. Age, body weight, atrial fibrillation, baseline NIHSS scores, and levels of fibrinogen are risk factors for early neurological deterioration after intravenous thrombolysis in patients with acute cerebral infarction.

Key words： acute cerebral infarction intravenous thrombolysis early neurological deterioration risk factors

Received: 02 August 2019

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	Articles by authors
	QIN Jinbiao
	ZHU Min
	LIU Gaofei
	CHENG Yishun
	and FENG Wei

Cite this article:

QIN Jinbiao,ZHU Min,LIU Gaofei等. Risk factors for early neurological deterioration after intravenous thrombolysis in patients with acute cerebral infarction[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2020, 31(1): 16-19.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2020/V31/I1/16

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