硝酸盐和亚硝酸盐转化为NO的方式、途径及其对心血管疾病治疗研究进展

Abstract
Figure/Table
References
Related Citation (15)

[1]	Gluvic Z M, Obradovic M M, Sudar E M, et al. Regulation of nitric oxide production in hypothyroidism[J]. Biomed Pharmacother, 2020,124(1): 109881.
[2]	Carlstrom M, Montenegro M F. Therapeutic value of stimulating the nitrate-nitrite-nitric oxide pathway to attenuate oxidative stress and restore nitric oxide bioavailability in cardiorenal disease[J]. Intern Med, 2019, 285(1): 2-18.
[3]	Zalutskaya Z, Kochemasova L, Ermilova E. Dual positive and negative control of Chlamydomonas PII signal transduction protein expression by nitrate/nitrite and NO via the components of nitric oxide cycle[J]. BMC Plant Biol, 2018, 18(1): 305.
[4]	解龙辉, 王淑芳, 赵建荣, 等. 螺内酯在改善血液透析患者心血管功能中的作用[J]. 武警医学, 2019, 30(8): 687-689.
[5]	Kemmner S, Lorenz G, Wobst J, et al. Dietary nitrate load lowers blood pressure and renal resistive index in patients with chronic kidney disease: a pilot study[J]. Nitric Oxide, 2017, 64(4): 7-15.
[6]	侯春丽, 孙建. 短时静脉输注亚硝酸钠对心衰患者心肺血液动力学的影响[J]. 实用药物与临床, 2016, 19(2): 164-168.
[7]	黄雅, 王瑛, 尤国兴, 等. 不同氧化模型制备时红细胞聚集性和变形性的变化[J]. 中国输血杂志, 2015, 28(6): 620-623.
[8]	Meiying Y, Yanji X, Heisner J S, et al. Peroxynitrite nitrates adenine nucleotide translocase and voltage-dependent anion channel 1 and alters their interactions and association with hexokinase II in mitochondria[J]. Mitochondrion, 2019, 46(5):380-392.
[9]	Petrick H L, Brunetta H, Kirsh A, et al. 75-OR: dietary nitrate and fecal transplantation prevent cardiac dysfunction and attenuate left ventricular mitochondrial reactive oxygen species emission in high-fat diet-fed mice[J]. Diabetes, 2020, 69(5): 609-621.
[10]	刘莉, 叶鹏. 膳食硝酸盐通过减少交感神经过度激活的机制降低血管紧张素Ⅱ诱导的高血压大鼠的血压[J]. 中华高血压杂志, 2019, 27(3): 203.
[11]	Ling W C, Murugan D D, Lau Y S, et al. Sodium nitrite exerts an antihypertensive effect and improves endothelial function through activation of eNOS in the SHR[J]. Sci Rep, 2016, 6(9): 33048.
[12]	袁瑞雪, 涂生芬, 陈萍, 等. 亚硝酸钠对高肺血流肺动脉高压大鼠的影响及机制研究[J]. 重庆医科大学学报, 2016, 41(12): 1216-1221.
[13]	Stanaway L, Rutherfurd K, Page R, et al. Acute Supplementation with nitrate-rich beetroot juice causes a greater increase in plasma nitrite and reduction in blood pressure of older compared to younger adults[J]. Nutrients, 2019, 11(7): 1683.
[14]	Jones T, Dunn EL, Macdonald J H, et al. The effects of beetroot juice on blood pressure, microvascular function and large-vessel endothelial function: a randomized, double-blind, placebo-controlled pilot study in healthy older adults[J]. Nutrients, 2019, 11(8): 1792.
[15]	Blekkenhorst L C, Lewis J R, Prince R L, et al. Nitrate-rich vegetables do not lower blood pressure in individuals with mildly elevated blood pressure: a 4-wk randomized controlled crossover trial[J]. Am J Clin Nutr, 2018, 107(6): 894-908.
[16]	Tropea T, Renshall L J, Nihlen C, et al. Beetroot juice lowers blood pressure and improves endothelial function in pregnant eNOS mice: importance of nitrate-independent effects[J]. Physiol (Lond.), 2020, 12(5): 1-10.
[17]	Kina M, Sakanashi M, Tanimoto A, et al. Long-term dietary nitrite and nitrate deficiency causes the metabolic syndrome, endothelial dysfunction and cardiovascular death in mice[J]. Diabetologia, 2017, 60(6): 1138-1151.
[18]	Montenegro M F, Amaral J H, Pinheiro L C, et al. Sodium nitrite downregulates vascular NADPH oxidase and exerts antihypertensive effects in hypertension[J]. Free Radic Biol Med, 2011, 51(1): 144-152.
[19]	Dezfulian C, Shiva S, Alekseyenko A, et al. Nitrite therapy after cardiac arrest reduces reactive oxygen species generation, improves cardiac and neurological function, and enhances survival via reversible inhibition of mitochondrial complex I[J]. Circulation, 2009, 120(10): 897-905.
[20]	Kramkowski K, Leszczynska A, Przyborowski K, et al. Short-term treatment with nitrate is not sufficient to induce in vivo antithrombotic effects in rats and mice[J]. Naunyn Schmiedebergs Arch Pharmacol, 2017, 390(1): 85-94.
[21]	Velmurugan S, Kapil V, Ghosh S M, et al. Antiplatelet effects of dietary nitrate in healthy volunteers: involvement of cGMP and influence of sex[J]. Free Radic Biol Med, 2013, 65(12): 1521-1532.
[22]	Srihirun S, Schechter A N, Piknova B. Platelet-based detection of nitric oxide in blood by measuring vasp phosphorylation[J]. J Vis Exp, 2019, 143(11): e58647.
[23]	Burnley H N, Abdul F, Androshchuk V, et al. Dietary nitrate supplementation reduces circulating platelet-derived extracellular vesicles in coronary artery disease patients on clopidogrel therapy: a randomised, double-blind, placebo-controlled study[J]. Thromb Haemost, 2018, 118(1): 112-122.
[24]	Khalaf A, Babiker F. Discrepancy in calcium release from the sarcoplasmic reticulum and intracellular acidic stores for the protection of the heart against ischemia/reperfusion injury[J]. J Physiol Biochem, 2016, 72(3): 495-508.
[25]	Björnsson B, Bojmar L, Olsson H, et al. Nitrite, a novel method to decrease ischemia/reperfusion injury in the rat liver[J]. World J Gastroenterol, 2015, 21(6): 1775-1783.
[26]	Wang Y, Song X, Yue X, et al. Protection by nitrite against the ischemic effects induced by acute myocardial infarction in mice[J]. Anatol J Cardiol, 2017, 18(5): 315-320.
[27]	Jeddi S, Khalifi S, Ghanbari M, et al. Effects of Nitrate intake on myocardial ischemia-reperfusion injury in diabetic rats[J]. Arq Bras Cardiol, 2016, 107(4): 339-347.
[28]	Salloum F N, Sturz G R, Yin C, et al. Beetroot juice reduces infarct size and improves cardiac function following ischemia-reperfusion injury: possible involvement of endogenous H2S[J]. Exp Biol Med (Maywood), 2015, 240(5): 669-681.
[29]	Lee J W, Lee D-H, Park J K, et al. Sodium nitrite-derived nitric oxide protects rat testes against ischemia/reperfusion injury[J]. Asian J Androl, 2018, 21(1): 92-97.
[30]	Henrohn D, Björkstrand K, Lundberg J O, et al. Effects of oral supplementation with nitrate-rich beetroot juice in patients with pulmonary arterial hypertension-results from beet-pah, an exploratory randomized, double-blind, placebo-controlled, crossover study[J]. J Card Fail, 2018, 24(10): 640-653.
[31]	Tawa M, Yano Y, Yamanaka M, et al. Effects of beet juice supplementation on monocrotaline-induced pulmonary hypertension in rats[J]. Am J Hypertens, 2019, 32(2): 216-222.
[32]	Cortés P I, Sun J, Schechter A N, et al. Inhaled nebulized nitrite and nitrate therapy in a canine model of hypoxia-induced pulmonary hypertension[J]. Nitric Oxide, 2019, 91(10): 1-14.

[1]	. [J]. Med. J. Chin. Peop. Armed Poli. Forc., 2020, 31(2): 93-96.