可手术的非小细胞肺癌患者TUBB3基因mRNA表达与预后相关性

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Abstract Objective To evaluate the correlations between the expression of TUBB3 mRNA and the prognosis of NSCLC patients who can be treated surgically. Methods The expression of TUBB3 gene mRNA was detected with branch DNA liquid chips in 92 NSCLC patients who were followed up for 60 months. Results Low expressions of TUBB3 promised longer overall survival (48.7 vs 35.8 months, HR=1.56, 95% CL:1.45-2.56, P=0.017) in these patients. The median progression-free survival was longer in patients with low expressions of TUBB3 mRNA than in those with high expressions (35.7 months vs 23.5 months, P=0.001, HR=1.33,95% Cl:1.06-2.32). Conclusions TUBB3 mRNA expressions may be a factor that can help predict the prognosis of NSCLC patients.

Key words： NSCLC TUBB3 overall survival progression-free survival prognostic factor

Received: 10 December 2019

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	Articles by authors
	ZHAO Yunlong
	LI Jingbo
	ZHAO Yingnan
	CHEN Ping
	LIU Bo
	LIU Yang

Cite this article:

ZHAO Yunlong,LI Jingbo,ZHAO Yingnan等. Correlations between expressions of TUBB3 gene mRNA and prognosis in 92 patients of non-small cell lung cancer[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2020, 31(5): 397-400.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2020/V31/I5/397

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