血清淀粉样蛋白A对2型糖尿病患者不良心血管事件的影响

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Abstract Objective To investigate the effects of serum amyloid A (SAA) on adverse cardiovascular events in patients with type 2 diabetes. Methods A total of 98 patients with type 2 diabetes diagnosed in Beijing Armed Police Corps Hospital between March to December of 2016 were selected as the subjects. These patients were followed up for two years and divided into the occurrence group (n=38) and the non-occurrence group (n=60). The clinical characteristics of the two groups were compared. Correlations between SAA and adverse cardiovascular events were analyzed, and the ROC curve was used to analyze the predictive value of SAA for adverse cardiovascular events. Results Of the 98 cases, 38 experienced adverse cardiovascular events (occurrence group), accounting for 38.8% and including 18 cases of acute coronary syndrome (47.4%), 12 cases of heart failure (31.6%), 6 cases of symptomatic arrhythmias (15.8%), 1 case of cardiac arrest (2.6%), and 1 case of death (2.6%). By contrast, 60 cases reported no adverse cardiovascular events (non-occurrence group), accounting for 61.2%. The proportion of patients with adverse cardiovascular events who were sixty or above and complicated with hypertension was significantly higher in the occurrence group than in the non-occurrence group, and the difference was statistically significant (P<0.05). The level of LVEF in patients with adverse cardiovascular events was significantly lower in the occurrence group than in the non-occurring group, and the difference was also statistically significant (P<0.05). Multivariate Logistic regression model analysis suggested that age ≥60 years and elevated levels of low-density lipoprotein, CRP, homocysteine and SAA were independent risk factors for adverse cardiovascular events in patients with type 2 diabetes (P<0.05). The AUC of CRP was 0.6186, and the diagnostic cutoff was 4.81,compared with 0.7248 and 10.96 for SAA. Conclusions Patients with type 2 diabetes are at higher risk of adverse cardiovascular events within 2 years. Patients aged 60 or above, with high LDL-C levels of low-density lipoprotein, CRP, homocysteine and SAA are more susceptible to adverse cardiovascular events. Elevated SAA levels are of predictive value for the risk of adverse cardiovascular events in patients with type 2 diabetes.

Key words： serum amyloid A type 2 diabetes adverse cardiovascular events correlation

Received: 05 January 2020

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	Articles by authors
	ZHU Xinjian
	DONG Yuehua
	LI Pengyu
	XI Xiaoping

Cite this article:

ZHU Xinjian,DONG Yuehua,LI Pengyu等. Effects of serum amyloid A on adverse cardiovascular events in patients with type 2 diabetes[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2020, 31(6): 516-519.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2020/V31/I6/516

[1]	常程,潘一龙,杜洪姣,等. 血清淀粉样蛋白A水平与冠状动脉粥样硬化的研究进展[J]. 中国心血管病研究, 2019, 17(10):942-945.
[2]	Raggi P,Genest J, Giles J T,et al.Role of inflammation in the pathogenesis of atherosclerosis and therapeutic interventions[J].Atherosclerosis,2018,276:98-108.
[3]	朱国富,李希杰,阮志敏,等. 血清淀粉样蛋白 A 与老年冠心病患者冠状动脉病变严重程度的相关性分析[J]. 中华老年心脑血管病杂志, 2016,18(11):1161-1164.
[4]	Kim M H,Beer M C,Wroblewski J M,et al.Impactofindividual acute phase serunl amyloid A isoforms on HDL metabolism in mice[J].J Lipid Res,2016,57(6):969-979.
[5]	李成,周健. 2019年ADA糖尿病医学诊疗标准解读[J]. 中国医学前沿杂志(电子版),2019, 11(1):66-74.
[6]	张璐璐,刘芸,段文冰,等. 血清淀粉样蛋白 A 与冠心病的相关性研究[J]. 新医学, 2019,50(1): 11-15.
[7]	玛依拉·卡哈尔,哈丽达·木沙,李雅丽,等.老年 2 型糖尿病和冠心病患者高密度脂蛋白与高密度脂蛋白中血清淀粉样蛋白A含量改变的相关性[J].中国老年学杂志,2018,38(10):2320-2322.
[8]	Pedicino D, Vinci R,Giglio A F,et al.Alterations of hyaluronan metabolism in acute coronary syndrome: implicationsfor plaque erosion[J].J Am Coil Cardiol,2018, 72(13):1490-1503.
[9]	毛从答, 李玲玲, 牛兆青, 等. 血清RBP4、MCP-1、SAA水平变化与缺血性脑卒中老年患者NIHSS评分的相关性[J]. 武警医学,2019,30(8):693-696.
[10]	谭保林. 血清淀粉样蛋白A在疾病应用中的研究进展[J]. 中国社区医师,2019,35(3):9-10,12.
[11]	程龙强. 冠心病患者的血清淀粉样蛋白A与C反应蛋白水平及其与病变严重程度的相关性[J]. 广西医学,2018,40(16):1815-1817.
[12]	史际华, 崔建娇. 冠心病患者CTRP9、APN、SAA、hs-CRP水平与冠脉斑块稳定性的相关性[J]. 中国老年学杂志, 2018, 38(14): 3365-3368.
[13]	邢金梅,崔秀卿,时岩, 等. 益气活血解毒汤联合前列腺素E1治疗糖尿病合并冠心病疗效及对血液流变学、血清淀粉样蛋白A、Hcy水平的影响[J]. 现代中西医结合杂志, 2018,27(29):3213-3215,3223.
[14]	谭学君,刘娟棻,唐文江,等. 老年稳定型冠心病血清淀粉样蛋白A和一氧化氮与不良心血管事件的相关性[J]. 临床心血管病杂志,2019,35(11):1006-1010.
[15]	Page M J,Thomson G J,Nunes J M,et al.Serum amyloid a binds to fibrin(ogen), promoting fibrin amyloid formation[J]. Sci Rep,2019,9(1):3102.
[16]	陈强, 陈丽珠,张娟, 等. 冠心病患者PCI术后24 h血清hs-CRP、SAA水平对支架内再狭窄的预测价值[J]. 山东医药,2018,58(4):48-50.