老年人血脑屏障通透性、缺血性脑白质高信号严重程度与认知功能的关系

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Abstract Objective To explore the relationships between blood-brain barrier permeability and WMH severity and cognitive function in elderly patients with ischemic white matter hyperintensity (WMH). Methods One hundred and twenty elderly patients with ischemic WMH and 120 elderly healthy people were selected between January 2018 and January 2021, who were randomly divided into the observation group and control group. According to results of magnetic resonance imaging (MRI), the indexes of blood-brain barrier permeability were compared between the two groups. According to Fazekas scores, elderly patients with ischemic WMH were divided into three groups:mild (Fazekas score of 0-2), moderate (Fazekas score of 3-4) and severe (Fazekas score of 5-6). The cognitive function of these patients was evaluated. The blood-brain barrier permeability indexes and cognitive function indexes of patients with different levels of severity of WMH were compared. Results The osmotic transport rate and the area under the osmotic curve in normal areas of the white matter of the brain were significantly higher in the observation group than in the control group (P<0.05). The difference in the osmotic transport rate and areas under osmotic curves were statistically significant between mild, moderate and severe WMH groups (P<0.05), which were the highest in the severe WMH group. MMSE scores and MoCA scores were significantly different between the three groups (P<0.05), and they were the highest in the mild WMH group, followed by the moderate WMH group and severe WMH group. According to correlation analysis, the osmotic transport rate and the area under the osmotic curve of elderly patients with ischemic WMH were positively correlated with the severity of WMH (P<0.05), but were negatively correlated with MMSE scores and MoCA scores (P<0.05). Conclusions The permeability of blood-brain barriers increases with the severity of WMH. The stronger the permeability of blood-brain barriers is, the more serious the cognitive impairment becomes.

Key words： ischemic white matter hyperintensity blood-brain barrier permeability severity cognitive function correlation

Received: 10 May 2021

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R743.33

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	Articles by authors
	XU Yanjie
	CHEN Weiqi
	YANG Zhiqiang
	WANG Rui
	GUO Jiangtao
	WANG Yilong

Cite this article:

XU Yanjie,CHEN Weiqi,YANG Zhiqiang等. Relationships between blood-brain barrier permeability and WMH severity and cognitive function in elderly patients with ischemic white matter hyperintensity[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2021, 32(10): 864-867.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2021/V32/I10/864

[1]	Scott J A, Braskie M N, Tosun D,et al. Cerebral amyloid is associated with greater white-matter hyperintensity accrual in cognitively normal older adults[J]. Neurobiol Aging, 2016, 48:48-52.
[2]	Ogama N, Yoshida M, Nakai T,et al. Frontal white matter hyperintensity predicts lower urinary tract dysfunction in older adults with amnestic mild cognitive impairment and Alzheimer's disease[J]. Geriatr Gerontol Int, 2016, 16(2):167-174.
[3]	Havenon A, Wong K H, Elkhetali A,et al. Carotid artery stiffness accurately predicts white matter hyperintensity volume 20 years later: a secondary analysis of the atherosclerosis risk in the community study[J]. AJNR Am J Neuroradiol, 2019, 40(8):1369-1373.
[4]	陈慧敏,张美美,王伊龙.增龄相关脑白质高信号与帕金森病脑萎缩及认知障碍的相关性[J].中华医学杂志,2020,100(43):3397-3401.
[5]	李悦,李曼,杨磊,等.老年脑白质高信号患者血脑屏障破坏与认知功能的相关性研究[J].中华老年心脑血管病杂志,2020,22(12):1239-1242.
[6]	Bahrani A A, Powell D K, Yu G,et al. White matter hyperintensity associations with cerebral blood flow in elderly subjects stratified by cerebrovascular risk[J]. J Stroke Cerebrovasc Dis, 2017, 26(4):779-786.
[7]	Dalen J W, Mutsaerts H, Nederveen A J,et al. White matter hyperintensity volume and cerebral perfusion in older individuals with hypertension using arterial spin-labeling[J]. AJNR Am J Neuroradiol, 2016, 37(10):1824-1830.
[8]	Aljondi R, Szoeke C, Steward C,et al. The effect of midlife cardiovascular risk factors on white matter hyperintensity volume and cognition two decades later in normal ageing women[J]. Brain Imaging Behav,2020,14(1):51-61.
[9]	李曼,李悦,高帅,等.动态增强MRI定量评价缺血性脑白质病患者血脑屏障通透性[J].中国医学影像技术,2018,34(2):181-184.
[10]	邓云,徐俊.血脑屏障通透性定量评估在老年脑小血管疾病中的应用[J].实用老年医学,2020,34(11):1194-1197.
[11]	陈政宇,陆小伟,赵慧慧,等.老年人脑白质高信号的影响因素及与认知功能障碍的关系[J].中国神经免疫学和神经病学杂志,2020,27(5):367-372.
[12]	王兴,陈奕奕.脑小血管病脑白质高信号与认知障碍的关系研究进展[J].中国卒中杂志,2019,14(11):1146-1152.
[13]	李琳琳,张伊湄,张伟,等.脑白质高信号和多发性腔隙性梗死的步态障碍特点及其与认知功能的相关性研究[J].临床医学研究与实践,2020,5(10):13-16,19.
[14]	胡玉敏.血管性认知障碍患者认知功能与脑白质高信号相关性分析[J].中国医药导报,2018,15(36):178-180.
[15]	王诗男,王金芳,石庆丽,等.脑白质高信号合并认知障碍患者脑白质损伤程度的评价[J].中华行为医学与脑科学杂志,2020,29(6):546-550.