P型多系统萎缩的神经影像征象分析

Abstract
Figure/Table
References (22)
Related Citation (15)

Download: PDF (853 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract

Objective To analyze slit-like putaminal hypointensity on T₂-weighted imaging, and putaminal hypointensity on DWI,pontine atrophy and middle cerebellar peduncle atrophy in patients with multiple system atrophy-parkinsonian type(MSA-P). Methods Twenty patients with MSA-P and another 20 age-matched healthy subjects were enrolled. The scanning protocol included FSE T₂WI sequences on standard sagittal and axial views,T₁ FLAIR sequence on the axial view,and diffusion weighted imaging(DWI) sequence on the axial view. Atrophy of the pons and middle cerebellar peduncle,slit-like putaminal hypointensity on T₂-weighted imaging,and putaminal hypointensity on DWI were all evaluated. Results Puaminal hypointensity on DWI was observed in 90%(18/20)of the patients,slit-like putaminal hypointensity on T₂-weighted imaging in 70% (14/20), unilateral or bilateral middle cerebellar peduncle atrophy in 40%(8/20),and pontine atrophy in 30%(6/20).The slit-like putaminal hypointensity on T₂-weighted imaging and putaminal hypointensity on DWI were significantly different between MSA-P patients and controls (P＜0.01). Conclusions The slit-like putaminal hypointensity on T₂-weighted imaging and putaminal hypointensity on DWI are more common among MSA-P patients. The incidence of putaminal hypointensity on DWI is higher than that of slit-like putaminal hypointensity on T₂-weighted imaging in patients with MSA-P.

Key words： magnetic resonance imaging, diffusion weighted putaminal multiple system atrophy,Parkinsonian type Parkinson disease

Received: 08 January 2021

ZTFLH:

R445.2

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHENG Kuihong
	ZHANG Jing
	HU Jianfeng
	LU Qiaohui
	LI Xiaojuan

Cite this article:

ZHENG Kuihong,ZHANG Jing,HU Jianfeng等. MR neuroimaging features of multiple system atrophy-parkinsonian type[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2021, 32(7): 573-576.

URL:

http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2021/V32/I7/573

[1]	Fanciulli A, Stankovic I, Krismer F, et al. Multiple system atrophy [J]. Int Rev Neurobiol, 2019,149(3):137-192.
[2]	Gilman S, Wenning G K, Low P A, et al. Second consensus statement on the diagnosis of multiple system atrophy [J]. Neurology, 2008, 71(5): 670-676.
[3]	肖慧,胡万鹏,孙实香, 等. MRI测量橄榄-桥脑-小脑萎缩[J]. 上海医学影像杂志,2002, 11 (1):24-27.
[4]	朱江. 磁共振测量小脑中脚宽度在多系统萎缩与帕金森病鉴别诊断中的价值[J]. 世界最新医学信息文摘, 2017, 17(28): 26-28.
[5]	Palma J A, Norcliffe K L, Kaufmann H. Diagnosis of multiple system atrophy [J]. Auton Neurosci, 2018, 211(5): 15-25.
[6]	Burn D J, Jaros E, Share C. Multiple system atrophy: cellular and molecular pathology [J]. Mol Pathol, 2001, 54(6): 419-426.
[7]	Lee Y H, Ando T, Lee J J, et al. Later-onset multiple system atrophy: a multicenter Asian study [J]. Mov Disord, 2020, 35(9): 1692-1693.
[8]	Paviour D C, Price S L, Lees A J, et al. Regional brain volumes distinguish PSP, MSA-P, and PD: MRI-based clinico-radiological correlations [J]. Mov Disord, 2006, 21(7): 989-996.
[9]	Paviour D C, Price S L, Jahanshahi M. Longitudinal MRI in progressive supranuclear palsy and multiple system atrophy: rates and regions of atrophy [J]. Brain, 2006, 129(4): 1040-1049.
[10]	于静,王晓,胡君, 等. MRI形态学测量对帕金森病、多系统萎缩及进行性核上性麻痹的鉴别诊断价值[J]. 临床神经病学杂志, 2019, 32(6): 406-409.
[11]	Ito S, Shirai W, Hattori T. Evaluating posterolateral linearization of the putaminal margin with magnetic resonance imaging to diagnose the Parkinson variant of multiple system atrophy [J]. Mov Disord, 2007, 22(4): 578-581.
[12]	Ito S, Shirai W, Hattori T. Putaminal hyperintensity on T1-weighted MR imaging in patients with the Parkinson variant of multiple system atrophy[J]. AJNR Am J Neuroradiol, 2009, 30(6): 689-692.
[13]	Block S A, Bakshi R. FLAIR MRI of striatonigral degeneration [J]. Neurology, 2001, 56(9): 1200.
[14]	Sugiyama A, Ito S, Suichi T, et al. Putaminal hypointensity on T2-weighted MR imaging is the most practically useful sign in diagnosing multiple system atrophy: a preliminary study [J]. J Neurol Sci, 2015, 349(2): 174-178.
[15]	Matsusue E, Fujii S, Kanasaki Y, et al. Putaminal lesion in multiple system atrophy: postmortem MR pathological correlations [J]. Neuroradiology, 2008, 50(6): 559-567.
[16]	Lewinski F, Werner C, Jorn T, et al. T2*-weighted MRI in diagnosis of multiple system atrophy: a practical approach for clinicians [J]. J Neurol, 2007, 254(9): 1184-1188.
[17]	Arabia G, Morelli M, Paglionico S, et al. A magnetic resonance imaging T2-weighted sequence at short echo time to detect putaminal hypointensity in Parkinsonisms [J]. Mov Disord, 2010, 25(11): 2728-2734.
[18]	Kraft E, Trenkwalder C, Auer D P. T2-weighted MRI differentiates multiple system atrophy from Parkinson's disease [J]. Neurology, 2002, 59(6): 1265-1267.
[19]	Wang Y, Butros S R, Shuai X, et al. Different irondeposition patterns of multiple system atrophy with predominant parkinsonism and idiopathetic Parkinson diseases demonstrated by phase-corrected susceptibility weighted imaging system atrophy from Parkinson's disease [J]. Am J Neuroradiol, 2012, 33(3): 266-273.
[20]	Gupta D, Saini J, Kesavadas C, et al. Utility of susceptibilityweighted MRI in differentiating Parkinson's disease and atypical Parkinson syndromes[J]. Neuroradiology, 2010, 52(10): 1087-1094.
[21]	Haller S, Badoud S, Nguyen D, et al. Differentiation between Parkinson disease and other forms of Parkinsonism using support vector machine analysis of susceptibility-weighted imaging (SWI): initial results system atrophy from Parkinson's disease [J]. Eur Radiol, 2013, 23(1):12-19.
[22]	Mazzucchi S, Frosini D, Costagli M, et al. Quantitative susceptibility mapping in atypical Parkinsonisms system atrophy from Parkinson's disease [J]. Neuroimage Clin, 2019, 24(8): 559-567.