G蛋白β<sub>3</sub>亚单位C825T基因多态性与富马酸比索洛尔降压疗效的相关性

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Abstract Objective To study the correlations between Gnβ3-C825T gene polymorphism and the antihypertensive effect of bisoprolol fumarate.Methods Inpatients and outpatients with low-grade and moderate-grade hypertension treated in the First Medical Center received 5 mg/d bisoprolol orally. Their Gnβ₃-C825T genotypes were detected, According to genotypes, these patients were divided into three groups: CC type, CT type and TT type groups, with 150 participants in each group. They were followed up 7 days, 1, 3 and 6 months after treatment.The blood concentration of bisoprolol fumarate was measured.24-hour dynamic blood pressure was recorded, and systolic blood pressure and diastolic blood pressure (SBP and DBP) under resting state were compared.24 h mean systolic blood pressure (24 h SBP), 24 h mean diastolic blood pressure (24 h DBP), daytime mean systolic blood pressure (D SBP), daytime mean diastolic blood pressure (D DBP), night mean systolic blood pressure (N SBP) and night mean diastolic blood pressure (N DBP) were compared between these groups.24-hour dynamic electrocardiograms were recorded to compare the 24-hour average heart rate and the heart rate turbulence (HRT) level.Results The blood concentration of bisoprolol fumarate in the TT group was higher than in the other two groups, and the difference was statistically significant (P< 0.05), but there was no statistically significant difference between the CC group and CT group. There was no significant difference in blood concentration between these patients 1, 3 and 6 months after treatment. After the application of bisoprolol fumarate, blood pressure of the three groups trended down, and the antihypertensive effect was the best in the TT group, followed by the CT group and CC group, and there was statistically significant difference in blood pressure reduction between the three groups (P<0.05). After 7 days of treatment, dynamic electrocardiograms showed that the heart rate of the three groups began to decrease, and there was statistically significant difference between the TT group and the other two groups, but not between the CT group and the CC group. The level of heart rate turbulence (HRT) in the TT group is better than in the other two groups.Conclusions The polymorphism of Gnβ3-C825T genes is correlated with the antihypertensive efficacy of bisoprolol fumarate.

Key words： Gnβ3-C825T gene high blood pressure bisoprolol fumarate

Received: 20 March 2021

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	WEI Yu
	ZHANG Lan
	WANG Chi
	ZHU Hang

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WEI Yu,ZHANG Lan,WANG Chi等. Correlations between Gnβ₃-C825T polymorphism and the antihypertensive effect of bisoprolol fumarate[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2021, 32(8): 662-666.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2021/V32/I8/662

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