莫达非尼改善健康成年人认知功能的Meta分析

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Abstract Objective To determine the efficacy of modafinil for cognitive enhancement in healthy adults by means of literature retrieval and meta-analysis. Methods Such databases as Pubmed, Web of Science and Cochrane Library were extensively searched. Eligible randomized clinical trials that evaluated the efficacy of modafinil versus placebo for cognitive function in healthy adults were included and analyzed by using RevMan5.4. Results A total of 14 trials involving 7 crossover studies(n=248) and 7 parallel studies(n=328, 143 of the cases received modafinil and 185 received placebo) were included in the final analysis. Generic inverse variance meta-analysis indicated that there was statistically significant difference in the overall effect between modafinil and placebo(SMD=0.11, 95%CI=0.02-0.21,Z=2.46,P=0.01,I²= 70%). Subgroup analysis did not indicate significant difference in cognitive function tests between different groups. Conclusions Modafinil can help improve cognition to some extent. Because of the limited evidence available, further studies are needed to elucidate the applicability of modafinil as a “smart” drug.

Key words： modafinil cognitive function healthy people meta-analysis

Received: 03 May 2021

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R971.7

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	Articles by authors
	TAO Tianzhu
	WANG Yi
	XU Yuhai
	ZHANG Guorong
	DENG Lve
	LIU Jun
	YANG Xiaoming

Cite this article:

TAO Tianzhu,WANG Yi,XU Yuhai等. Efficacy of modafinil for cognitive enhancement in healthy adults: a meta-analysis[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2022, 33(1): 22-26.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2022/V33/I1/22

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