高血压伴糖耐量减低患者血压晨峰与靶器官损伤的相关性

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (560 KB) HTML (0 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the correlations between the morning blood pressure surge(MBPS) and target organ damage in patients with hypertension and impaired glucose tolerance.Methods Two hundred and ten primary hypertension patients with impaired glucose tolerance(IGT) were divided into the MBPS group (n=100) and non-MBPS group (n=110). The carotid intima-media thickness (IMT), carotid artery plaque (CA), left ventricular hypertrophy and hypertension fundus artery lesions, and urinary albumin/creatinine (MAU) were determined to assess the target organ damage by MBPS.Results The 24 h mean systolic blood pressure [(136.24±10.59) mmHg], daytime systolic blood pressure [(140.32±12.09) mmHg]and diastolic blood pressure [(86.7±9.40) mmHg], IVST [(12.2±1.4)mm], VPWT[(12.6±2.7)mm], LVEDD[(54.2±7.6)mm], LVMI[(147.2±29.8) g/m²),and IM [(1.28±0.32)mm)were all higher in the MBPS group than in the non-MBPS group. The detection rates of carotid plaque (47.0%), left ventricular hypertrophy (44.0%)and hypertensive fundus lesions (63.0%) in the MBPS group were significantly higher than those of the non-MBPS group (33.0%, 27.3%, 46.4%).Conclusions For patients with hypertension with reduced glucose tolerance, MBPS can lead to the increase of IVST, LVPWT, LVEDD, LVMI, IMT, left ventricular hypertrophy and the incidence of hypertensive fundus lesions. Therefore, measures should be taken to control the MBPS in patients with hypertension complicated with IGT.

Key words： hypertension impaired glucose tolerance morning blood pressure surge target organ damage

Received: 22 July 2021

ZTFLH:

R-33

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHANG Cunxin
	CHEN Junhua

Cite this article:

ZHANG Cunxin,CHEN Junhua. Relationships between morning blood pressure surge and target organ damage among patients with hypertension and impaired glucose tolerance[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2022, 33(4): 327-330.

URL:

http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2022/V33/I4/327

[1]	中华医学会心血管病学分会高血压学组. 清晨血压临床管理的中国专家指导建议[J]. 中华心血管病杂志, 2014, 42(9):721-725.
[2]	中国高血压防治指南修订委员会,高血压联盟(中国), 中华医学会心血管病学分会,等.中国高血压防治指南(2018年修订版)[J]. 中国心血管病杂志,2019,24(1):24-56.
[3]	中华医学会糖尿病学分会,中华医学会内分泌学会分会. 中国成人2型糖尿病患者糖化血红蛋白控制目标及达标策略专家共识[J].中华糖尿病杂志,2020,12(1):1-12.
[4]	中国高血压防治指南修订委员会. 中国高血压防治指南2010[J]. 中国高血压杂志,2011,39(7):701-743.
[5]	Wong T Y, Mitchell P. Hypertensive retinopathy[J]. N Engl J Med,2004,351(22):2310-2317.
[6]	黄义波, 陈源源. 清晨血压研究进展[J].中华老年心脑血管病杂志, 2019, 21(6):651-653.
[7]	Ding S F, Ni M, Liu X L, et al. A causal relationship between shear stress and atherosclerotic lesions in apolipoprotein E knockout mice assessed by ultrasound biomicroscope[J]. Am J Physical Heart Cire Physiol,2010,298(6):1743-1782.
[8]	Johnson A W, Hissen S L, Macefield V G, et al. Magnitude of morning surge in blood pressure is associated with sympathetic but not cardiac baroreflex sensitivity[J]. Front Neurosci, 2016,10(5): 412-413.
[9]	Cheng H M, Wu C L, Sung S H, et al. Prognostic utility of morning blood pressure surge for 20 -year all-cause and cardiovascular mortalities: results of a community-based study[J]. J Am Heart Assoc, 2017, 6(12): e007667.
[10]	Yoo J K, Sun D D, Parker R S, et al.Augmented venoarteriolar response with ageing is associated with morning blood pressure surge[J].Exp Physiol, 2018, 103(11):1448-1455.
[11]	Yoda K, Inaba M, Hamamoto K, et al.Association between glycemic control and morning blood pressure surge with vascular endothelial dysfunction in type 2 diabetic patients[J].Diabetes Care,2014,115(3):644-650.
[12]	王丽娜,孙俐俐,段丽敏,等.高血压合并糖代谢异常患者动脉粥样硬化状况的临床研究[J].黑龙江医药科学,2011,34(2): 79-80.
[13]	刘建勋,李建彬, 武恩平, 等.郑州市成人高血压人群糖代谢异常流行现状与危险因素[J].中华健康管理学杂志, 2019,11(4):314-318.
[14]	Koc A S, Gorgulu F F, Donmez Y, et al.There is a significant relationship between morning blood pressure surge and increased abdominal aortic intima-media thickness in hypertensive patients[J]. J Med Ultrason, 2018,45(4):597-603.
[15]	蒋海霞. 老年原发性高血压患者血压晨峰现象对靶器官损伤和心脑血管事件发生的影响[J].中国药物与临床, 2019,19(15): 2633-2636.
[16]	Wang J G, kario K, Chen C H, et al. Management of morning hypertension: a consensus statement of an Asian expert panel[J]. J Clin Hypertens(Greenwich), 2018, 20(1):39-44.
[17]	Turak O, Afsar B, Siriopol D, et al.Morning blood pressure surg as a predictor of development of chronic kidney disease[J]. J Clin Hypertens(Greenwich),2016, 18 (5):444-448.