METTL3在早期鳞状细胞宫颈癌中的表达及其与临床特征和预后的关系

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Abstract Objective To investigate the relationship between the expression of METTL3 and its clinical features and prognosis in early-stage squamous cell cervical cancer.Methods This study included paraffin samples from 110 patients with cervical cancer who underwent radical hysterectomy from January 2008 to December 2008. Immunohistochemistry was used to detect the METTL 3 expression in tumor specimens and non-tumor cervical tissues, and patients were divided into high-expression group and low-expression group. Kaplan-Meier survival analysis was used to determine the relationship between the expression level of METTL 3 and prognosis. Cox proportional hazard regression analysis was used to analyze the influencing factors of poor prognosis of early cervical cancer patients.Results The expression level of METTL3 in tumor tissues of patients with cervical cancer was significantly lower than that in normal cervical specimens (P<0.01). Low METTL3 expression was associated with higher FIGO staging (P=0.041) and pelvic lymph node metastasis (P=0.001). Kaplan-Meier survival analysis showed that low METTL3 expression was associated with worse overall survival (HR=3.576, 95%CI=1.474-8.677, P=0.0048). Cox multivariate analysis showed that FIGO installment (HR=5.109, 95% CI: 1.891-11.135, P<0.01), pelvic metastases (HR=2.395, 95 % CI: 1.156-4.879, P<0.05),and low expression of METTL3(HR=6.187, 95% CI: 2.314-21.292, P=0.004) were the independent prognostic factor in patients with early cervical cancer.Conclusion METTL3 expression level has decreased significantly in cervical cancer tissue. The FIGO staging, pelvic lymph node metastasis and METTL3 expression levels are independent indicators for poor prognosis of patients with early squamous cell cervical cancer.

Key words： cervical cancer METTL3 prognosis survival analysis

Received: 10 March 2022

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	WANG Caixia
	LU Han
	ZHOU Hong
	SHUAI Hanlin
	LI Yujie

Cite this article:

WANG Caixia,LU Han,ZHOU Hong等. Analysis of relationship between the expression of METTL3 and its clinical features and prognosis in early-stage squamous cell cervical cancer[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2022, 33(8): 645-649.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2022/V33/I8/645

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