雌激素受体α基因SNP12(rs6932902)位点多态性与隐睾相关性的Meta分析

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Abstract Objective To explore the relationship between SNP12(rs6932902) polymorphism of estrogen receptor α gene and cryptorchidism.Methods The case-control studies involving the association of estrogen receptor α gene rs6932902 polymorphism with the susceptibility to cryptorchidism were retrieved through computer-based search in PubMed, Embase, EBSCO, CNKI, CBM,VIP and Wan Fang Data(1990.01-2021.05).The statistical analysis was performed by STATA 12.0 software. Pooled odds ratio (OR) and 95% confidence interval (CI)were calculated,and the sensitivity analysis and publication bias were carried out.Results A total of four case-control studies were included for the meta-analysis. The analysis revealed that there was a significant association of estrogen receptor α rs6932902 polymorphism with the risk of cryptorchidism A vs. G [OR=0.987,95%CI(0.594,1.612), P=0.931]; dominant model: AA+GA vs. GG [OR=0.845,95%CI(0.494,1.446), P=0.539]; recessive model: AA vs. GA＋AA [OR=1.946,95%CI(1.005,3.767), P=0.048]; co-dominant model: GA vs. GG [OR=0.729,95%CI(0.451,1.180), P=0.198]; co-dominant model: AA vs. GG [OR=1.863,95%CI(0.947,3.663), P=0.071];over-dominant: GG+AA vs. GA [OR=1.549,95%CI(1.150,2.209), P=0.005)].Conclusions Estrogen receptor α rs6932902 polymorphism may be significantly associated with the susceptibility to cryptorchidism. The AA genotype or AA+GG genotype increases the risk of cryptorchidism in either recessive or super dominant inheritance.

Key words： estrogen receptor α gene SNP12 cryptorchidism Meta-analysis

Received: 24 April 2022

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	LI Sijie
	NING Wei
	WANG Yangcai

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LI Sijie,NING Wei,WANG Yangcai. Meta-analysis of the association between estrogen receptor α SNP12 (rs6932902) locus polymorphism and cryptorchidism[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2023, 34(2): 104-107.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2023/V34/I2/104

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