高原驻训官兵肝功能损害状况及其与海拔高度的相关性

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Abstract Objective To understand the status of liver function of officers and soldiers stationed on plateau and analyze its correlation with altitude. Methods Five hundred and seventy-five liver function reports were randomly selected from the physical examination reports of officers and soldiers stationed in Aba prefecture, Sichuan Province. According to the altitude, they were divided into three groups: 144 cases in the < 2000 m group, 192 cases in the 2000-3000 m group and 239 cases in the >3000 m group. The liver function indicators studied included total bilirubin, indirect bilirubin, direct bilirubin, total protein, albumin, globulin, white globulin ratio, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, γ-Glutamyl transpeptidase and total bile acids. If any liver function indicator exceeded its normal range, it was judged as abnormal liver function. Results Of all the study objects, 198 cases (34.4%) had abnormal liver function, and the numbers of abnormal serum bilirubin, abnormal serum protein, abnormal serum transaminase and elevated total bile acid were 140 cases (24.3%) , 32 cases (5.6%) , 70 cases (12.2%) , and 15 cases (2.6%) respectively. The grouping study showed that the incidences of abnormalities of total bilirubin, indirect bilirubin, total bile acids, alanine aminotransferase, γ-Glutamyltranspeptidase, alkaline phosphatase, total protein, albumin and leukocyte ratio in >3000 m group were significantly higher than that in< 2000 m group and 2000-3000 m group (P<0.05), however, there was no significant difference between < 2000 m group and 2000-3000 m group (P>0.05). There was no significant difference in the incidence of abnormalities of direct bilirubin, aspartate aminotransferase and globulin among the three groups (P>0.05). Conclusions Abnormal liver function is common in officers and soldiers stationed at high altitude, and mainly manifested as the abnormalities of indirect bilirubin, total bilirubin and alanine aminotransferase. The damage of liver function is positively correlated with altitude, and mainly occurs in plateau area above 3000 meters, which needs to be paid special attention to.

Key words： plateau officers and soldiers abnormal liver function altitude

Received: 15 September 2022

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	ZENG Renpan
	WANG Danling
	QIAN Ping

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ZENG Renpan,WANG Danling,QIAN Ping. Liver function impairment of officers and soldiers stationed on plateau and its correlation with altitude[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2023, 34(4): 291-294.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2023/V34/I4/291

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[1]	. [J]. Med. J. Chin. Peop. Armed Poli. Forc., 2023, 34(4): 366-368.