头颈部鳞状细胞癌自噬相关LncRNA预后风险模型的建立

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Abstract Objective To investigate the prognostic role of autophagy-related LncRNA in patients with head and neck squamous cell carcinoma (HNSCC), and to construct a prognostic risk model for HNSCC.Methods HNSCC sequencing data and clinical data were downloaded from the Cancer Genome Atlas (TCGA), and autophagy datasets were downloaded from the HADb database. Person correlation analysis was used to identify HNSCC autophagy-related LncRNA, and univariate Cox regression analysis to screen for correlation with the prognosis of HNSCC The autophagy-related LncRNA was further analyzed by multivariate Cox multifactor regression analysis was used to determine the autophagy-related LncRNA with independent prognostic significance. Based on these autophagy-related LncRNAs, a risk model was constructed, patients were divided into a high-risk group and a low-risk group, and the survival differences between the two groups were compared. ROC curve analysis was used to evaluate the predictive ability of the model's prognosis, and finally Cox regression was used to analyze the relationship between risk score, clinicopathological features and the prognosis of HNSCC patients.Results A total of 9 HNSCC autophagy-related LncRNAs(LINC02195, AP003068.1, LINC02560, MIR9-3HG, AC106820.3, AC040977.1, AC005288.1, AC104083.1, AC098487.1)were identified and a risk model was constructed. The 5-year overall survival rate of patients in the high-risk group (48.40%,103/219)was significantly shorter than that of the low-risk group (70.45%,155/220)(P<0.05). The area under the ROC analysis curve was 0.715, which showed that the risk model had a good ability to predict the prognosis of HNSCC patients. And multivariate Cox regression analysis showed that risk score (HR= 1.984,95%CI:1.350-2.916)was an independent prognostic risk factor for HNSCC.Conclusions The prognostic risk model based on 9 autophagy-related LncRNAs can be used to predict the prognosis of HNSCC patients, and these autophagy-related LncRNAs may play an important role in the biology of HNSCC.

Key words： autophagy head and neck squamous cell carcinoma LncRNA prognosis model

Received: 09 March 2023

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	Articles by authors
	XIE Zhimin
	LI Qingzhu
	WANG Jiefeng
	GUO Youling
	GONG Xiaoyan
	GAO Qian

Cite this article:

XIE Zhimin,LI Qingzhu,WANG Jiefeng等. Establishment of autophagy-related LncRNA prognostic risk model for head and neck squamous cell carcinoma[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2023, 34(8): 693-697.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2023/V34/I8/693

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