脐带间充质干细胞鞘内移植治疗不完全性颈髓损伤的疗效和安全性

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Abstract Objective To study the therapeutic effect of umbilical cord mesenchymal stem cell (UC-MSC) transplantation on incomplete cervical spinal cord injury. Methods 39 patients with incomplete cervical spinal cord injury were enrolled and received 4 times of UC-MSC transplantation through the pathways of lumbar puncture. ASIA scores and the Barthel index of activities of daily living (ADL) were used to assess the motion and sensory function, musclar tention, and activities of daily living of spinal cord patients before and half a year after the transplantation. Results The patients had improvement in their motion function, sensory function, musclar tention, and activities of daily living. And the most significant improvement was motor function, the scores changed from 61±22 before operation to 70±18 at 6 month after the transplantation. No obvious adverse reactions occurred, such as surgical site infection, cerebrospinal fluid leakage and central nervous system infection, etc. 15.4% of patients experienced fever in 24 hours after operation, 7.7% of patients experienced low intracranial pressure and 5.1% of patients experienced flank and lower limber pain. Conclusions UC-MSC transplantation significantly improves the sensory function, motion function, function of urination and defecation and perspiration in patients with incomplete cervical spinal cord injury with few adverse reactions.

Key words： umbilical cord mesenchymal stem cell spinal cord injury cell transplantation

Received: 15 November 2014

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	WANG Peishen
	LIU Xuebin
	YI Long
	DAI Guanghui
	ZHANG Zan
	AN Yihua

Cite this article:

WANG Peishen,LIU Xuebin,YI Long等. Effect and safety of umbilical cord mesenchymal stem cell transplantation in treatment of incomplete cervical spinal cord injury[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2015, 26(3): 282-285.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2015/V26/I3/282

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