|
|
Correlations between D-dimer and leukocyte levels in patients with traumatic brain injury |
WANG Xinyuan1, ZHOU Ning1, ZHU Feng1, ZHANG Hui1, HUANG Yong2, XU Nuo1 |
1. Department of Clinical Laboratory, 2. Department of Neurosurgery, Jiangsu Provincial Corps Hospital, Chinese People’s Armed Police Force, Yangzhou 225003, China |
|
|
Abstract Objective To explore the significance of increased levels of plasma D-dimer (D-D) and relevant white blood cell (WBC) variation for patients with brain trauma.Methods Medical data on two hundred and forty-six cases of patients with craniocerebral trauma was retrospectively analyzed, while another thirty-five healthy people were randomly selected as control. D-D levels and whole blood cells were tested for the first time after hospitalization. Abnormally elevated D-D levels and correlated changes of WBC parameters were statistically analyzed.Results For patients with traumatic brain injury, the D-D concentration was (8.20±5.93) mg/L, WBC(12.54±3.59)×109/L, NEU%(89.97±9.40)% and NEU# was (10.82±3.22)×109/L, which were significantly higher than in the healthy control group(0.19±0.12) mg/L, (6.15±0.92)×109/L, (60.28±9.05)% and (4.36±0.11)×109/L (P<0.01) respectively. The degree of elevated D-D was positively correlated with WBC, NEU% and NEU# in blood cell parameters (P<0.01), but negatively correlated with LYM% and LYM# (P<0.05). The difference was statistically significant.Conclusions The degree of D-D and WBC of patients are higher than those of healthy people. The degree of elevated D-D is positively correlated with WBC for patients with brain trauma.
|
Received: 20 March 2017
|
|
|
|
|
[1] |
张均迈.急性颅脑伤外伤后凝血功能及D-二聚体变化临床观察[J].中国实用神经疾病杂志,2014,17(3):46-47.
|
[2] |
周良辅. 重型颅脑损伤后凝血功能障碍的诊断和治疗 [J].中华创伤杂志,2015,31(8): 673-675.
|
[3] |
魏 俊,杨 珉,王 戚,等.颅脑损伤并发脑梗死的相关性因素分析[J].中华全科医学,2012,10(10):1573-1574.
|
[4] |
武晓灵,喻 莉,龙 鼎. suPAR及D-二聚体对创伤性颅脑损伤患者病情严重程度及预后的判断价值 [J]. 实用医学杂志,2017,33(2):234-237.
|
[5] |
陈文远,陈锋龙,龙建武,等.颅脑损伤后并发脑梗死的危险因素分析[J].福建医药杂志,2014,36(4):43-45.
|
[6] |
Tong W S, Zheng P, Zeng J S. Prognosis and risk factors related to progressive intracranial haemonhage in patients with acute traumatic brain injury [J]. Brain In J, 2013,26(9):1136-1142.
|
[7] |
王晓锋,李海水,王生虎,等. 脑外伤患者血浆D-D、CRP和Fb的检测及临床观察[J].放射免疫学杂志,2012,25(3): 309-312.
|
[8] |
赵鹏洲,柯以铨,吴敬伦,等. 重型颅脑损伤患者颅内压与神经元入特异性烯醇化酶D-二聚体及C反应蛋白的相关性研究 [J].中华神经医学杂志,2015,14(5): 506-510.
|
[9] |
肖志强,司金春,许志杰,等.全身炎症反应综合征修正评分及白细胞监测鉴别脑外伤患者应激反应与早期感染的价值[J].中华实验和临床感染杂志,2012,8(2):245-248.
|
[10] |
朴 影,徐树军,王 赞,等. NT-proBNP和D-二聚体水平变化与脑梗死损伤程度的相关性分析[J]. 中风与神经疾病杂志,2014,31(11):998-1001.
|
[11] |
张 俊.外周血白细胞计数与脑外伤后进展性出血性损伤的相关性分析 [J].浙江创伤外科,2014,19(1):47-48.
|
[12] |
韩永峰,李 翔.急性颅脑损伤患者血清D-二聚体检测的临床意义[J].医药前沿,2015,5(36):51-53.
|
[1] |
. [J]. Med. J. Chin. Peop. Armed Poli. Forc., 2019, 30(8): 718-719. |
|
|
|
|