大剂量瑞舒伐他汀联合疏血通注射液对不稳定型心绞痛患者血清HIF-1α、sCD40L水平变化的影响

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Abstract Objective To investigate the effect of large doses of rosuvastatin combined with Shuxuetong injection on the changes of electrocardiograms and serum levels of hypoxia inducible factor -1α (HIF-1α) and soluble CD40 ligand L (sCD40L) in patients with unstable angina pectoris(UAP).Methods A total of 108 cases of UAP patients treated in our hospital between July 2014 and September 2017 were selected and divided into the experimental group and the control group according to the random number table,each with 54 cases. Both groups were given conventional treatment. In addition,the control group was treated with high-dose rosuvastatin,while the experimental group was treated with high-dose rosuvastatin combined with Shuxuetong injection. Both groups were treated for 14 days. The clinical effect,difference in electrocardiograms and incidence of adverse reactions of the two groups were statistically recorded. The hemorheological indexes (fibrinogen,hematocrit and plasma viscosity) and serum levels of HIF-1α and sCD40L were compared between the two groups before treatment and after 14 days of treatment.Results After 14 days of treatment, the total effective rate and rate of clinical effect on electrocardiograms in the experimental group were 83.33% and 87.04% respectively, higher than 61.11% and 68.52% of the control group(P<0.05). After 14 days of treatment, the levels of fibrinogen and hematocrit and plasma viscosity of the experimental group were (3.69±0.64)g/L, (0.37±0.08)% and (1.40±0.25)mPa·s respectively, lower than (4.31±0.76)g/L, (0.48±0.10)% and (1.63±0.38)mPa·s of the control group(P<0.05). After 14 days of treatment, the levels of serum HIF-1α and sCD40L of the experimental group were (426.27±17.40)pg/ml and (11.03±1.22)μg/L respectively, lower than (532.43±19.15)pg/ml and (14.27±1.40)μg/L of the control group(P<0.05). There was insignificant difference in the incidence of adverse reactions between the experimental group (14.81%) and the control group (11.11%)(P>0.05).Conclusions Large doses of rosuvastatin combined with Shuxuetong injection in treating patients with unstable angina pectoris can significantly improve the clinical effect and the patients’ electrocardiograms,reduce the levels of serum HIF-1α and sCD40L,and improve hemorheology. Moreover, this approach is quite safe.

Key words： unstable angina pectoris rosuvastatin Shuxuetong injection electrocardiogram HIF-1α sCD40L hemorheology

Received: 10 January 2018

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	MENG Bin
	WANG Sheng.

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MENG Bin,WANG Sheng.. Effects of Large Doses of Rosuvastatin Combined with Shuxuetong Injection on Changes of Electrocardiograms and Serum Levels of HIF-1α and sCD40L in Patients with Unstable Angina Pectoris[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2018, 29(6): 582-585.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2018/V29/I6/582

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