CDCA8基因表达与膀胱癌患者临床病理和预后的相关性

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Abstract Objective To investigate the expression of CDCA8 in bladder cancer (BC), to clarify the relationships between CDCA8 expressions and clinicopathological characteristics of BC and the prognostic value of CDCA8 in BC, and to evaluate the mechanism of CDCA8 in BC.Methods The bladder cancer sample expression profiles including CDCA8 expression data and its clinical information were downloaded from GEO datasets. The expression of CDCA8 in bladder cancer was analyzed by non-paired t test. The correlations between CDCA8 gene expression and the clinicopathologic features were analyzed by Chi-square test. Overall survival and specific survival were analyzed using Log-rank method. GSEA(gene set enrichment analysis)was conducted to explore the associated gene sets regulated by CDCA8.Results The expression of CDCA8 was up-regulated in BC (8.870±0.08281 vs 7.472±0.07035, P<0.0001). CDCA8 expression was significantly associated with age(P=0.027), gender(P=0.04), progression(P=0.001),T stage(P<0.0001), N stage(P=0.013)and grade(P<0.0001). Higher expressions of CDCA8 predicted both poor specific survival in BC(P<0.0001, HR= 0.5177, 95% CI: 13.40-18.10) and poor overall survival in BC(P<0.0001, HR=0.09906, 95% CI: 5.971-16.38). The Results of GSEA indicated that CDCA8 regulated gene sets associated with spermatogenesis, G₂M checkpoint, E₂F targets, Myc targets, mTORC1 signaling, mitotic spindle angiogenesis, PI3K/AKT/mTOR signaling, cholesterol homeostasis and glycolysis.Conclusions CDCA8 is highly expressed in BC, correlated with worse clinicopathological features and acts as a prognostic marker and target in the diagnosis and treatment of patients with BC.

Key words： bladder cancer CDCA8 clinical significance

Received: 20 November 2017

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R737.14

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	Articles by authors
	BI Yaqiong
	CHEN Song
	JIANG Jiazhi
	SHI Hongjie
	LI Sheng

Cite this article:

BI Yaqiong,CHEN Song,JIANG Jiazhi等. Expression of CDCA8 in bladder cancer and its clinical significance[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2018, 29(8): 750-754.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2018/V29/I8/750

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