富马酸伏诺拉生治疗Hp阳性消化性溃疡的临床效果

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摘要目的探讨富马酸伏诺拉生治疗幽门螺杆菌(Hp)阳性消化性溃疡(PU)的临床效果。方法选取2022-05至2024-04空军军医大学第二附属医院消化内科门诊Hp阳性PU患者94例,随机分为对照组和研究组,每组47例。对照组给予阿莫西林+胶体果胶铋+克拉霉素+奥美拉唑治疗,研究组口服阿莫西林+胶体果胶铋+克拉霉素+富马酸伏诺拉生,治疗2周。比较两组患者溃疡愈合情况、Hp根除情况、临床疗效、胃酸分泌功能及安全性。结果研究组溃疡愈合率为93.62%(44/47),高于对照组的78.72%(37/47),差异有统计学意义(P＜0.05)。与对照组相比,研究组Hp根除率较高(87.23% vs. 68.09%,P＜0.05)。研究组临床疗效总有效率较高(82.29% vs. 95.74%, χ²=7.029,P＜0.05)。治疗后,两组基础胃酸分泌量(BAO)、最大胃酸分泌量(MAO)和高峰胃酸分泌量(PAO)均下降,且研究组BAO、MAO和PAO分别为(4.15±1.44)mmol/h、(8.02±2.13)mmol/h和(12.12±3.67)mmol/h,均低于对照组[(5.36±1.98)mmol/h、(10.15±2.99)mmol/h和(15.01±3.59)mmol/h(t=3.388、3.978、3.859,P＜0.05)]。两组不良反应发生率比较,差异无统计学意义(4.26% vs.10.64%,P＞0.05)。结论富马酸伏诺拉生治疗Hp阳性PU疗效优,可促溃疡愈合,抑胃酸分泌,安全性好。

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	刘小刚
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	刘成文

关键词 ：消化性溃疡, 幽门螺杆菌, 富马酸伏诺拉生, 胃酸分泌功能

Abstract：Objective To investigate the clinical effect of fumarate in the treatment of Helicobacter pylori (Hp) positive peptic ulcer (PU). Methods A total of 94 HP-positive PU patients from the gastroenterology outpatient department of the Second Affiliated Hospital of Air Force Military Medical University from May 2022 to April 2024 were selected and randomly divided into control group and study group with 47 cases in each group. The control group was treated with amoxicillin + bismuth colloid pectin + clarithromycin + omeprazole, while the study group was treated with amoxicillin + bismuth colloid pectin + clarithromycin + fumarate Vonorazine orally for 2 weeks. The ulcer healing, Hp eradication, clinical efficacy, gastric acid secretion function and safety of the two groups were compared. Results The ulcer healing rate of the study group was 93.62% (44/47) higher than that of the control group (78.72% (37/47), and the difference was statistically significant (P<0.05). Compared with the control group, the eradication rate of Hp in the study group was higher (87.23% vs. 68.09%, P<0.05). The total effective rate of the two groups was higher in the study group (82.29% vs. 95.74%, χ²=7.029, P<0.05). After treatment, basal gastric acid secretion (BAO), maximum gastric acid secretion (MAO) and peak gastric acid secretion (PAO) decreased in both groups. The BAO, MAO and PAO levels in the study group were (4.15±1.44) mmol/h, (8.02±2.13) mmol/h and (12.12±3.67) mmol/h lower than those in the control group (5.36±1.98) mmol/h, (10.15±2.99) mmol/h and (15.01±3.59) mmol/h (t=3.388, 3.978, 3.859, P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (4.26% vs. 10.64%, P>0.05). Conclusions The treatment effect of fumarate on Hp positive PU is excellent, which is worthy of promotion due to the promotion of ulcer healing, inhibition of gastric acid secretion and its safety.

Key words： peptic ulcer helicobacter pylori Vonorazine fumarate gastric acid secretion function

收稿日期: 2024-07-09

ZTFLH:

R573.1

基金资助:陕西省重点研发计划项目(2023-SF-32)

通讯作者: 杨婷,E-mail:tingtingla@163.com

作者简介: 刘小刚,硕士研究生,副主任医师。

引用本文:

刘小刚, 张娇娇, 杨婷, 刘成文. 富马酸伏诺拉生治疗Hp阳性消化性溃疡的临床效果[J]. 武警医学, 2025, 36(1): 30-33. LIU Xiaogang, ZHANG Jiaojiao, YANG Ting, LIU Chengwen. Clinical effect of fumarate on Hp positive peptic ulcer. Med. J. Chin. Peop. Armed Poli. Forc., 2025, 36(1): 30-33.

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https://journal08.magtechjournal.com/Jwk_wjyx/CN/ 或 https://journal08.magtechjournal.com/Jwk_wjyx/CN/Y2025/V36/I1/30

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