Spagnolo P,Molyneaux P L,Bernardinello N,et al.The role of the lung＇s microbiome in the pathogenesis and progression of idiopathic pulmonary fibrosis[J].Int J Mol Sci,2019,20(22):5618-5630.
Wuyts W A,Wijsenbeek M,Bondue B,et al.Idiopathic pulmonary fibrosis: best practice in monitoring and managing a relentless fibrotic disease[J].Respiration,2020,99(1):73-82.
[4]
Pardo A,Selman M.The interplay of the genetic architecture,aging,and environmental factors in the pathogenesis of idiopathic pulmonary fibrosis[J].Am J Respir Cell Mol Biol,2021,64(2):163-172.
Yang D,Chen X,Wang J,et al.Dysregulated lung commensal bacteria drive interleukin-17b production to promote pulmonary fibrosis through their outer membrane vesicles[J].Immunity,2019,50(3):692-706.
King TE,Pardo A,Selman M. Idiopathic pulmonary fibrosis[J].Lancet,2011,378(9807):1949-1961.
[11]
Hongjuan He,Xiaoyan Ji,Lihua Cao,et al. Medicine Targeting Epithelial-Mesenchymal Transition to Treat Airway Remodeling and Pulmonary Fibrosis Progression[J].Can Respir J,2023,e3291957.
[12]
X. Liang,X. He,Y. Li,et al. Lyn regulates epithelial-mesenchymal transition in CS-exposed model through Smad2/3 signaling[J].Respir Res,2019,20(1):201-213.
[13]
Hill C,Li J,Liu D,et al. Autophagy inhibition mediated epithelial-mesenchymal transition augments local myofibroblast differentiation in pulmonary fibrosis[J].Cell Death Dis,2019,10(8):591-602.
[14]
S. Li,G. Liu,M. Gu,et al. A novel therapeutic approach for IPF: based on the “Autophagy-Apoptosis” balance regulation of Zukamu granules in alveolar macrophages[J].J Ethnopharmacol,2022,297:e115568.
[15]
G. Fan,J. Liu,Z. Wu,et al.Development and validation of the prognostic model based on autophagyassociated genes in idiopathic pulmonary fibrosis[J].Front Immunol,2022,13:e1049361.
[16]
YueLiang Yue,MengYu Zhang,JianYu Liu,et al. The role of autophagy in idiopathic pulmonary fibrosis: from mechanisms to therapies[J].Ther Adv Respir Dis,2022,16:1-21.
[17]
D. N. O'Dwyer,S. L. Ashley,and B. B. Moore. Influences of innate immunity,autophagy,and fibroblast activation in the pathogenesis of lung fibrosis[J].Am J Physiol Lung Cell Mol Physiol,2016,311(3):590-601.
Hongxia Tao,Qin Lv,Jing Zhang,et al. Different Levels of Autophagy Activity in Mesenchymal Stem Cells Are Involved in the Progression of Idiopathic Pulmonary Fibrosis[J].Stem Cells Int,2024,e3429565.
[20]
Gulati S,Thannickal VJ. The Aging Lung and ldiopathic Pulmonary Fibrosis [J].Am J Med Sci,2019,357 ( 5 ) :384-389.
[21]
Mora AL,Bueno M,Rojas M. Mitochondria in the spotlight of aging and idiopathic pulmonary fibrosis[J].Clin Invest,2017,127(2):405-414.
[22]
Leavy OC,Ma SF,Molyneaux PL,et al. Proportion of Idiopathic Pulmonary Fibrosis Risk Explained by Known Common Genetic Loci in European Populations[J].Am J Respir Crit Care Med,2021,203(6):775-778.
[23]
Fan YL,Ye Q.A concise review of telomere and telomerase-reated genetic markers in fibrotic lung diseases[J].Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi,2020,38(12):952-956.
[24]
Liu YY,Shi Y,Liu Y,et al. Telomere shortening activates TGF-β/Smads signaling in lungs and enhances both lipopolysaccharide and bleomycin-induced pulmonary fibrosis[J].Acta Pharmacol Sin,2018,39(11):1735-1745.
[25]
Duru N, Wolfson B, Zhou Q. Mechanisms of the alternative activation of macrophages and non-coding rnas in the development of radiation-induced lung fibrosis[J].World J Biol Chem,2016,7(4):231-239.
[26]
Miao C,Xiong Y,Zhang G,et al. MicroRNAs in idiopathic pulmonary fibrosis,new research progress and their pathophysiological implication[J].Exp Lung Res,2018,44(3):178-190.
[27]
Liang H,Gu Y,Li T,et al.Integrated analyses identify the involvement of microRNA-26a in epithelial-mesenchymal transition during idiopathic pulmonary fibrosis[J].Cell Death Dis,2014,5(5):1238-1249.
[28]
Shi L,Han O,Hong Y,et al. Inhibition of miR-199a-5p rejuvenates aged mesenchymal stem cells derived from patients with idiopathic pulmonary fibrosis and improves their therapeutic efficacy in expermental pulmonary fibrosis[J].Stem Cell Res Ther,2021,12(1):147-164.
[29]
Tian Chen,Lu Ding,Meiru Zhao,et al. Recent advances in the potential effects of natural products from traditional Chinese medicine against respiratory diseases targeting ferroptosis[J].Chinese Medicine,2024,19(1):49-82.
[30]
李 琦.异甘草素通过调控铁死亡抑制矽肺肺纤维化的机制研究[D].十堰:湖北医药学院,2021.
[31]
Jing Wen,Cui Wang,Li-Yun Song,et al. Ferroptosis Mediates Pulmonary Fibrosis: Implications for the Effect of Astragalus and Panax notoginseng Decoction[J].Can Respir J,2024:e5554886.
Bogdan A R,Miyazawa M,Hashimoto K,et al. Regulators of Iron Homeostasis:New Players in Metabolism,Cell Death,and Disease[J].Trends Biochem Sci,2016,41(3):274-286.
[34]
Pei Z,Qin Y,Fu X,et al. Inhibition of ferroptosis and iron accumulation alleviates pulmonary fibrosis in a bleomycin model[J].Redox Biol,2022,57:e102509.
[35]
Cheng H,Feng D,Li X,et al. Iron deposition-induced ferroptosis in alveolar type II cells promotes the development of pulmonary fibrosis[J].Biochim Biophys Acta Mol Basis Dis,2021,1867(12):e166204.
Lettieri,S.,Bertuccio,F.R.,del Frate,L,et al.The plastic interplay between lung regeneration phenomena and fibrotic evolution: current challenges and novel therapeutic perspectives[J].Int J Mol Sci,2024,25(1):547-574.
[26]
Miao C,Xiong Y,Zhang G,et al. MicroRNAs in idiopathic pulmonary fibrosis,new research progress and their pathophysiological implication[J].Exp Lung Res,2018,44(3):178-190.
[10]
King TE,Pardo A,Selman M. Idiopathic pulmonary fibrosis[J].Lancet,2011,378(9807):1949-1961.
[27]
Liang H,Gu Y,Li T,et al.Integrated analyses identify the involvement of microRNA-26a in epithelial-mesenchymal transition during idiopathic pulmonary fibrosis[J].Cell Death Dis,2014,5(5):1238-1249.
[11]
Hongjuan He,Xiaoyan Ji,Lihua Cao,et al. Medicine Targeting Epithelial-Mesenchymal Transition to Treat Airway Remodeling and Pulmonary Fibrosis Progression[J].Can Respir J,2023,e3291957.
[28]
Shi L,Han O,Hong Y,et al. Inhibition of miR-199a-5p rejuvenates aged mesenchymal stem cells derived from patients with idiopathic pulmonary fibrosis and improves their therapeutic efficacy in expermental pulmonary fibrosis[J].Stem Cell Res Ther,2021,12(1):147-164.
[12]
X. Liang,X. He,Y. Li,et al. Lyn regulates epithelial-mesenchymal transition in CS-exposed model through Smad2/3 signaling[J].Respir Res,2019,20(1):201-213.
[29]
Tian Chen,Lu Ding,Meiru Zhao,et al. Recent advances in the potential effects of natural products from traditional Chinese medicine against respiratory diseases targeting ferroptosis[J].Chinese Medicine,2024,19(1):49-82.
[13]
Hill C,Li J,Liu D,et al. Autophagy inhibition mediated epithelial-mesenchymal transition augments local myofibroblast differentiation in pulmonary fibrosis[J].Cell Death Dis,2019,10(8):591-602.
[30]
李 琦.异甘草素通过调控铁死亡抑制矽肺肺纤维化的机制研究[D].十堰:湖北医药学院,2021.
[14]
S. Li,G. Liu,M. Gu,et al. A novel therapeutic approach for IPF: based on the “Autophagy-Apoptosis” balance regulation of Zukamu granules in alveolar macrophages[J].J Ethnopharmacol,2022,297:e115568.
[31]
Jing Wen,Cui Wang,Li-Yun Song,et al. Ferroptosis Mediates Pulmonary Fibrosis: Implications for the Effect of Astragalus and Panax notoginseng Decoction[J].Can Respir J,2024:e5554886.
[15]
G. Fan,J. Liu,Z. Wu,et al.Development and validation of the prognostic model based on autophagyassociated genes in idiopathic pulmonary fibrosis[J].Front Immunol,2022,13:e1049361.
YueLiang Yue,MengYu Zhang,JianYu Liu,et al. The role of autophagy in idiopathic pulmonary fibrosis: from mechanisms to therapies[J].Ther Adv Respir Dis,2022,16:1-21.
[33]
Bogdan A R,Miyazawa M,Hashimoto K,et al. Regulators of Iron Homeostasis:New Players in Metabolism,Cell Death,and Disease[J].Trends Biochem Sci,2016,41(3):274-286.
[17]
D. N. O'Dwyer,S. L. Ashley,and B. B. Moore. Influences of innate immunity,autophagy,and fibroblast activation in the pathogenesis of lung fibrosis[J].Am J Physiol Lung Cell Mol Physiol,2016,311(3):590-601.
[34]
Pei Z,Qin Y,Fu X,et al. Inhibition of ferroptosis and iron accumulation alleviates pulmonary fibrosis in a bleomycin model[J].Redox Biol,2022,57:e102509.
Cheng H,Feng D,Li X,et al. Iron deposition-induced ferroptosis in alveolar type II cells promotes the development of pulmonary fibrosis[J].Biochim Biophys Acta Mol Basis Dis,2021,1867(12):e166204.
[19]
Hongxia Tao,Qin Lv,Jing Zhang,et al. Different Levels of Autophagy Activity in Mesenchymal Stem Cells Are Involved in the Progression of Idiopathic Pulmonary Fibrosis[J].Stem Cells Int,2024,e3429565.
Gulati S,Thannickal VJ. The Aging Lung and ldiopathic Pulmonary Fibrosis [J].Am J Med Sci,2019,357 ( 5 ) :384-389.
[37]
Lettieri,S.,Bertuccio,F.R.,del Frate,L,et al.The plastic interplay between lung regeneration phenomena and fibrotic evolution: current challenges and novel therapeutic perspectives[J].Int J Mol Sci,2024,25(1):547-574.
[21]
Mora AL,Bueno M,Rojas M. Mitochondria in the spotlight of aging and idiopathic pulmonary fibrosis[J].Clin Invest,2017,127(2):405-414.
[22]
Leavy OC,Ma SF,Molyneaux PL,et al. Proportion of Idiopathic Pulmonary Fibrosis Risk Explained by Known Common Genetic Loci in European Populations[J].Am J Respir Crit Care Med,2021,203(6):775-778.
[23]
Fan YL,Ye Q.A concise review of telomere and telomerase-reated genetic markers in fibrotic lung diseases[J].Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi,2020,38(12):952-956.
[24]
Liu YY,Shi Y,Liu Y,et al. Telomere shortening activates TGF-β/Smads signaling in lungs and enhances both lipopolysaccharide and bleomycin-induced pulmonary fibrosis[J].Acta Pharmacol Sin,2018,39(11):1735-1745.
[25]
Duru N, Wolfson B, Zhou Q. Mechanisms of the alternative activation of macrophages and non-coding rnas in the development of radiation-induced lung fibrosis[J].World J Biol Chem,2016,7(4):231-239.
[26]
Miao C,Xiong Y,Zhang G,et al. MicroRNAs in idiopathic pulmonary fibrosis,new research progress and their pathophysiological implication[J].Exp Lung Res,2018,44(3):178-190.
[27]
Liang H,Gu Y,Li T,et al.Integrated analyses identify the involvement of microRNA-26a in epithelial-mesenchymal transition during idiopathic pulmonary fibrosis[J].Cell Death Dis,2014,5(5):1238-1249.
[28]
Shi L,Han O,Hong Y,et al. Inhibition of miR-199a-5p rejuvenates aged mesenchymal stem cells derived from patients with idiopathic pulmonary fibrosis and improves their therapeutic efficacy in expermental pulmonary fibrosis[J].Stem Cell Res Ther,2021,12(1):147-164.
[29]
Tian Chen,Lu Ding,Meiru Zhao,et al. Recent advances in the potential effects of natural products from traditional Chinese medicine against respiratory diseases targeting ferroptosis[J].Chinese Medicine,2024,19(1):49-82.
[30]
李 琦.异甘草素通过调控铁死亡抑制矽肺肺纤维化的机制研究[D].十堰:湖北医药学院,2021.
[31]
Jing Wen,Cui Wang,Li-Yun Song,et al. Ferroptosis Mediates Pulmonary Fibrosis: Implications for the Effect of Astragalus and Panax notoginseng Decoction[J].Can Respir J,2024:e5554886.
Bogdan A R,Miyazawa M,Hashimoto K,et al. Regulators of Iron Homeostasis:New Players in Metabolism,Cell Death,and Disease[J].Trends Biochem Sci,2016,41(3):274-286.
[34]
Pei Z,Qin Y,Fu X,et al. Inhibition of ferroptosis and iron accumulation alleviates pulmonary fibrosis in a bleomycin model[J].Redox Biol,2022,57:e102509.
[35]
Cheng H,Feng D,Li X,et al. Iron deposition-induced ferroptosis in alveolar type II cells promotes the development of pulmonary fibrosis[J].Biochim Biophys Acta Mol Basis Dis,2021,1867(12):e166204.
2025, Vol. 36 
