摘要 目的 研究笑气（N 2O）清醒镇静在肠镜检查中的安全性和有效性。 方法 将 2011-04至2011-12在我院行笑气清醒 镇静肠镜检查的330例患者作为A组，同期常规肠镜检查300例患者作为B组，对其HR、SpO 2、反应情况及镇静效果等进行研 究分析。 结果 A组术中不适反应明显低于B组。A组中，术中HR低于术前［（74.90±13.65）次/min vs （79.16±14.67）次/min， P ＜0.05］，但术中HR在正常安全范围内；术中SpO 2高于与术前［99.64±1.04）% vs （99.14±1.35）%， P ＜0.05］。B组中，术中HR高于术前［（89.80±13.52） vs (79.77±13.35)， P ＜0.05］ ；术中SpO 2稍低于与术前［（99.42± 1.07 ）% vs (99.53±1.12)%］，但差异无统计学意义。 结论 笑气清醒镇静肠镜检查提高了肠镜检查的舒适度，安全、可行。
Abstract：Objective To study the safety and effectiveness of nitrous oxide (≤70%) for colonoscopy. Methods A total of 630 patients who underwent colonoscopy from April 2011 to December 2011 were divided into group A (nitrous oxide-colonoscopy group, n =330) and group B (conventional colonoscopy group, n =300). Their heart rate (HR), oxygen saturation and sedative effects were compared. Results The perioperative reaction in group A was obviously lower than in group B. In group A, the perioperative HR was obviously lower than the preoperative HR ［（74.90±13.65） vs (79.16±14.67)， P ＜0.05］ and the perioperative SpO2 was significantly higher than the preoperative SpO2 ［（99.64±1.04）% vs (99.14± 1.35)%， P ＜0.05］. In group B, the perioperative HR was significantly higher than the preoperative HR （89.80±13.52） vs (79.77±13.35)， P ＜0.05］ and the perioperative SpO2 was slightly higher than the preoperative SpO2 ［（99.64±1.04）% vs （99.14±1.35）%， P ＜0.05］，but the difference was not statistically significant. Conclusions Nitrous oxide for colonoscopy is comfortable, safe and feasible.
王寰，陈晓光，黎君，唐红卫，王伟岸，张建国，宋丽，刘海峰. 笑气清醒镇静对肠镜检查的有效性和安全性评价[J]. 武警医学, 2012, 23(6): 492-494.
WANG Huan, CHEN Xiaoguang, LI Jun, TANG Hongwei, WANG Weian, ZHANG Jianguo, SONG Li, and LIU Haifeng. Safety and efficacy of nitrous oxide for colonoscopy. Med. J. Chin. Peop. Armed Poli. Forc., 2012, 23(6): 492-494.
