Expression of Gli1 in breast infiltrating ductal carcinoma and its clinical significance
ZENG Peng1,2,HU Wei1,LI Li1,SU Dongwei1,LIU Xishui1,YU Yue1,and SHI Junyi1.
1. Department of Breast Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China; 2. The First Department of Surgery, Jiangxi Provincial Corps Hospital, Chinese People’s Armed Police Forces, Nanchang 330030, China
Abstract：Objective To investigate the expression of Glioma-associated Oncogene Homolog 1 (Gli1) in breast infiltrating ductal carcinoma and the clinical significance. Methods Gli1 expression in breast infiltrating ductal carcinoma and pericarcinomatous tissues was examined by Envison immunohistochemistry. The relationship between Gli1 expression, age, tumor size, clinical TNM stages, lymph node metastasis, Estrogen Receptor (ER), Progesterone Receptor (PR), P53, human epidermal growth factor receptor-2 (HER-2) expression in breast infiltrating ductal carcinoma was analyzed. Results GLi1 expression in breast infiltrating ductal carcinoma tissues was higher than in pericarcinomatous tissues (χ2=10.996,P <0.01). Gli1 expression was positively correlated with tumor size, P53 and clinical TNM stages, but not correlated with age, lymph node metastasis, ER, PR or HER-2. There was significant difference (χ2=4.621, χ2=4.332, χ2=4.601,P<0.05). Conclusion Gli1 expression is a new diagnostic parameter for breast carcinoma. It promotes tumor growth and development of clinical stages in breast infiltrating ductal carcinoma. Gli1 expression may be regulated by P53 expression.
2012, Vol. 23 
