Abstract： Objective To study the analgesic effect of intravenous lidocaine on postoperative pain of microvascular decompression. Methods Eighty patients scheduled for microvascular decompression were randomized into two groups, who either received placebo or lidocaine 1.5 mg/kg bolus before the induction of anesthesia followed by 2 mg/（kg·h）continuous IV. The patients underwent general anesthesia and postoperative pain was freated with patient-controlled IV fentanyl analgesia. The visual analog scale scores for pain and side effects were recorded at 2, 4, 6, 12, and 24 hours after surgery. Results The visual analog scale scores for pain at 2, 4, 6, 12, and 24 hours were lower in the lidocaine group than those in the placebo group（P<0.05）. The total dose of fentanyl (0-24 h after surgery) was lower in the lidocaine group than that in the placebo group（P<0.05）. The incidence of nausea and vomiting was smaller in the lidocaine group than that in the placebo group（P<0.05）. Conclusions Ⅳ lidocaine in microvascular decompression can reduce the fentanyl consumption and incidence of nausea and vomiting, which is a useful multimodal analgesic method.
孙永峰, 袁 俊, 翟卫东, 等. 面肌痉挛微血管减压术中责任血管的辨认与处理148例［J］.武警医学, 2007, 18(11): 874-875.［2］ Vigneault L, Turgeon A F, C té D, et al. Perioperative intravenous lidocaine infusion for postoperative pain control: a meta-analysis of randomized controlled trials［J］. Can J Anaesth, 2011, 58(1): 22-37.［3］ Sharma S, Rajagopal M R. A phase II pilot study to evaluate use of intravenous lidocaine for opioid-refractory pain in cancer patients［J］. Pain Symptom Manage, 2009, 37(1): 85-93.［4］ 罗先润, 魏 娜, 张 辉, 等.利多卡因对大鼠缺血脑损伤后Bax蛋白表达及细胞凋亡的影响［J］.武警医学, 2007, 18(12): 892-895.［5］ 崔伟华, 谭 红, 韩如泉, 等.小剂量利多卡因对丙泊酚诱导和维持效应的影响［J］.药物不良反应杂志, 2011, 13(1): 1-5.［6］ 刘纪泽, 曾宪阳.丙泊酚复合瑞芬太尼静脉麻醉应用研究进展［J］.武警医学, 2006, 17(9): 702-704.
［1］
孙永峰, 袁 俊, 翟卫东, 等. 面肌痉挛微血管减压术中责任血管的辨认与处理148例［J］.武警医学, 2007, 18(11): 874-875.［2］ Vigneault L, Turgeon A F, C té D, et al. Perioperative intravenous lidocaine infusion for postoperative pain control: a meta-analysis of randomized controlled trials［J］. Can J Anaesth, 2011, 58(1): 22-37.［3］ Sharma S, Rajagopal M R. A phase II pilot study to evaluate use of intravenous lidocaine for opioid-refractory pain in cancer patients［J］. Pain Symptom Manage, 2009, 37(1): 85-93.［4］ 罗先润, 魏 娜, 张 辉, 等.利多卡因对大鼠缺血脑损伤后Bax蛋白表达及细胞凋亡的影响［J］.武警医学, 2007, 18(12): 892-895.［5］ 崔伟华, 谭 红, 韩如泉, 等.小剂量利多卡因对丙泊酚诱导和维持效应的影响［J］.药物不良反应杂志, 2011, 13(1): 1-5.［6］ 刘纪泽, 曾宪阳.丙泊酚复合瑞芬太尼静脉麻醉应用研究进展［J］.武警医学, 2006, 17(9): 702-704.
2013, Vol. 24 
