摘要 目的 探讨吸烟及戒烟对健康男性动脉僵硬度的影响。方法 将47例具有长期吸烟史的健康男性分为继续吸烟组(26例)和戒烟组(21例);另选28例无吸烟史健康男性作为不吸烟组。采用脉搏波速度自动测量系统测定基线时和1个月、6个月时臂踝脉搏波速度(brachial–ankle pulse wave velocity,baPWV),用于评估动脉僵硬度。结果 基线时继续吸烟组和戒烟组较不吸烟组baPWV值升高(P<0.05)。1个月时戒烟组较继续吸烟组baPWV值差异无统计学意义(15.1 m/s vs 15.2 m/s,P>0.05),戒烟前后差异亦无统计学意义(P>0.05)。6个月时戒烟组较继续吸烟组baPWV值下降(14.2 m/s vs 15.3 m/s,P<0.05),且戒烟后baPWV值较戒烟前也下降(P<0.05)。结论 吸烟可以降低健康男性动脉弹性,戒烟1个月后动脉弹性无改善,但戒烟6个月后动脉弹性可出现改善。
Abstract：Objective To study the effects of smoking and smoking cessation on arterial hardness in healthy subjects. Methods Seventy-five chronic smoking healthy subjects were divided into maintaining smoking group (n=26) and ex-smoking group (n=21).Another 28 no-smoking healthy subjects were used as control group. The arterial hardness reflected by baPWV(brachial-ankle pulse wave velocity) was compared at baseline and after 1 month or 6 months of smoking cessation. Results The maintaining smoking group and ex-smoking group had higher values of baPWV than no-smoking group at baseline(P<0.05). After 1 month of smoking cessation, there was no difference in baPWV between maintaining smoking group and ex-smoking group(P>0.05), the same as between pre- and post-smoking cessation(P>0.05). After 6 month of smoking cessation, there was a decline in baPWV in ex-smoking group, when compared with maintaining smoking group(P<0.05). The same decrease was also observed between pre- and post-smoking cessation(P<0.05). Conclusions Smoking is associated with a decline of the arterial compliance, and 1 month of smoking cessation does not improve the arterial elasticity. But 6 months of smoking cessation improves the arterial elasticity.
孙敬杰,赵春华. 吸烟和戒烟对健康男性动脉僵硬度的影响[J]. 武警医学, 2013, 24(5): 390-392.
SUN Jingjie and ZHAO Chunhua. The Sanatorium of Chinese People’s Armed Police Forces,Sanya,China. Effects of smoking and smoking cessation on arterial hardness in healthy subjects. Med. J. Chin. Peop. Armed Poli. Forc., 2013, 24(5): 390-392.
Kubozono T, Miyata M, Ueyama K, et al. Acute and chronic effects of smoking on arterial stiffness[J]. Circulation journal : official journal of the Japanese Circulation Society, 2011,75(3):698-702.
[4]
O’Rourke M F, Hashimoto J. Mechanical factors in arterial aging: a clinical perspective[J]. Journal of the American College of Cardiology, 2007,50(1):1-13.
[1]
Cao X, Xiao H, Zhang Y, et al. 1, 5-Dicaffeoylquinic acid-mediated glutathione synthesis through activation of Nrf2 protects against OGD/reperfusion-induced oxidative stress in astrocytes[J]. Brain Res, 2010,1347:142-148.
[5]
Willum-Hansen T, Staessen J A, Torp-Pedersen C, et al. Prognostic value of aortic pulse wave velocity as index of arterial stiffness in the general population[J]. Circulation,2006,113(5):664-670.
[2]
Kim J W, Park C G, Hong S J, et al. Acute and chronic effects of cigarette smoking on arterial stiffness[J]. Blood pressure, 2005,14(2):80-85.
Kubozono T, Miyata M, Ueyama K, et al. Acute and chronic effects of smoking on arterial stiffness[J]. Circulation journal : official journal of the Japanese Circulation Society, 2011,75(3):698-702.
[4]
O’Rourke M F, Hashimoto J. Mechanical factors in arterial aging: a clinical perspective[J]. Journal of the American College of Cardiology, 2007,50(1):1-13.
[7]
Jatoi N A, Jerrard-Dunne P, Feely J, et al. Impact of smoking and smoking cessation on arterial stiffness and aortic wave reflection in hypertension[J]. Hypertension,2007,49(5):981-985.
[5]
Willum-Hansen T, Staessen J A, Torp-Pedersen C, et al. Prognostic value of aortic pulse wave velocity as index of arterial stiffness in the general population[J]. Circulation,2006,113(5):664-670.
[8]
Polonia J, Barbosa L, Silva J A, et al. Improvement of aortic reflection wave responses 6 months after stopping smoking: a prospective study[J]. Blood pressure monitoring,2009,14(2):69-75.
Jatoi N A, Jerrard-Dunne P, Feely J, et al. Impact of smoking and smoking cessation on arterial stiffness and aortic wave reflection in hypertension[J]. Hypertension,2007,49(5):981-985.
[8]
Polonia J, Barbosa L, Silva J A, et al. Improvement of aortic reflection wave responses 6 months after stopping smoking: a prospective study[J]. Blood pressure monitoring,2009,14(2):69-75.
2013, Vol. 24 
