Therapeutic effect of human umbilical cord mesenchymal stem cell transplantation on diabetic peripheral neuropathy
ZHENG Pei1,2,AN Yihua2,WANG Xiaodong2,HUA Rongrong2,ZHU Yan2,and MU Yiming1
1. Department of Endocrinology, General Hospital of PLA, Beijing 100853,China;
2. Department of Cell Therapy,The General Hospital of Chinese People’s Armed Police Forces,Beijing 100039,China
Abstract：Objective To observe the therapeutic effect of human umbilical cord mesenchymal stem cells (HUC-MSCs) transplantation on patients with diabetic peripheral neuropathy. Methods FBG,PBG,HbA1C levels,Toronto clinical scoring system(TCSS),electrophysiological examination were measured in 32 patients with diabetic peripheral neuropathy before and 1,3,6 months after they underwent HUC-MSCs transplantation. Observe the changes of clinical symptoms and the adverse reactions. Results The three follow-up results show that the FBG,PBG,HbA1C levels,TCSS,the distal motor latency of the median nerve,the sensory conduction velocity and the distal motor latency of the ulnar nerve , the positive rate of sensory conduction of the posterior tibial nerve, the distal motor latency and the positive rate of the sensory conduction of the common peroneal nerve all obviously improved. During the study period no adverse reaction occurred.The gross and fine motor function was most rapidly improved in 1 month afer the therapy and it could be continuously improved within 6 months after the therapy. Conclusions HUC-MSCs transplantation can significantly improve the clinical symptoms and electrophysiological examination of patients with diabetic peripheral neuropathy. It is a new safe, effective method to treat diabetic peripheral neuropathy.
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2013, Vol. 24 
