Changes of 5-hydroxytryptamine, heart rate variability, electrocardiographic characteristics and their mutual correlations in major depressive disorder patients of young soldiers in Armed Police Forces
HE Yan1,LV Jungang1,YANG Chunmei2,LIU Li1,WANG Songtao3,SUN Yanling4,XI Xiaoping5,CHEN Jiyang6
1.The Third Department of Internal Medicine, 3.Medical Department, 4. Phychology Department, 5. Electrocardiographic Room, 6. Clinic Laboratory, Beijing Municipal Corps Hospital, Chinese People’s Armed Police Forces, Beijing 10027, China;2.Jilin Provincial Corps Hospital, Chinese People’s Armed Police Forces, Changchun, China
Abstract：Objective To study the changes of 5-hydroxytryptamine ( 5-HT), heart rate variability ( HRV), electrocardiographic characteristics in major depressive disorder( MDD) patients and the correlation between 5-HT and MDD. Methods All subjects were divided into MDD group ( n=60) and control group ( n=40). Concentration of 5-HT in blood was determined by using liquid chromatograph mass spectrometry. We compared the concentrations of 5-HT between the two groups and analyzed the correlation between concentration of 5-HT and some factors’ scores in symptom checklist 90( scl-90). HRV was detected by Holter monitor. All subjects underwent the 12 lead electrocardiography and the Results were analyzed in detail. Results Concentration of 5-HT in the MDD group ( 172.08±101.36 ng/ml) was significantly lower than that in control group ( 257.34±104.06 ng/ml)( P＜0.001). Concentration of 5-HT in the MDD group was correlated with the Scl-90 score of interpersonal relationship( r=-0.406), depression ( r=-0.384) and hostility ( r=-0.445). All these correlations were significant( P＜0.01). The values of SDNN, SDANN, RmSSD, PNN50, LF, HF, LF/HF in the MDD group were lower than those in thecontrol group ( P＜0.001). More sinus bradycardia, sinus arrhythmia, early repolarization and premature beats were detected in the MDD group than in thecontrol group( P＜0.05). Conclusions It is very valuable to use concentration of 5-HT for diagnosing MDD. HRV and ECG are somewhat valuable for diagnosis of MDD.
贺延,吕俊刚,杨春梅,刘丽,王松涛,孙燕玲,席晓萍,陈激扬. 青年官兵血清5-羟色胺、心率变异、心电图特征与抑郁症的相关分析[J]. , 2013, 24(12): 1053-1055 .
HE Yan,LV Jungang,YANG Chunmei,LIU Li,WANG Songtao,SUN Yanling,XI Xiaoping,CHEN Jiyang. Changes of 5-hydroxytryptamine, heart rate variability, electrocardiographic characteristics and their mutual correlations in major depressive disorder patients of young soldiers in Armed Police Forces. , 2013, 24(12): 1053-1055 .
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