黄芩苷与红景天胶囊对急性高原病预防作用比较

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摘要目的探讨黄芩苷胶囊对急性高原病(acute mountain sickness, AMS)的预防作用。方法采用随机对照的研究方法, 80名急进高原健康男性青年随机分为3组, 黄芩苷组(n=32)、红景天组(n=24)和安慰剂组(n=24)。3组在进入高原前2 d、进入高原后连续3 d分别服用黄芩苷胶囊(0.5 g, 2次/d)、红景天胶囊(0.76 g, 2次/d)和安慰剂(2粒, 2次/d)。检测急进高原前(海拔397 m)和急进高原后(3658 m)受试者氧饱和度、心率、收缩压、舒张压, 彩色多普勒超声测量肺动脉收缩压(pulmonary artery systolic pressure, PASP)和平均肺动脉压(mean pulmonary arterial pressure, MPAP), 统计急进高原后各组的AMS发病率。结果急进高原后安慰剂组、黄芩苷组和红景天组的AMS发病率分别为58.3%(14/24)、25.0%(8/32)和29.2%(7/24), 与安慰剂组比较, 黄芩苷组及红景天组AMS发病率明显降低, 差异有统计学意义(P<0.05)。与急进高原前比较, 各组受试者急进高原后心率、血压及肺动脉压均升高, 氧饱和度降低(P<0.05);与安慰剂组比较, 黄芩苷组血压及心率明显降低(P<0.05), 红景天组急进高原后氧饱和度升高、肺动脉压降低(P<0.05)。结论黄芩苷组可能通过降低血压及心率预防AMS的发生, 红景天胶囊可能通过升高氧饱和度, 降低PASP、MPAP预防AMS的发生。

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	段炜
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	金峰
	陈虹

关键词 ：急性高原病, 黄芩苷胶囊, 红景天胶囊, 血压, 肺动脉压

Abstract：Objective To investigate the effect of baicalin capsules for acute mountain sickness(AMS) prevention with rapid airlift ascent to high altitude. Methods A randomized controlled trial was conducted on 80 healthy young men with baicalin capsules (0.5 g bid, n=32), rhodiola capsules (0.76 g bid, n=24), or placebo (n=24), for 2 days prior to airlift ascent (397 m) and for the first 3 days at high altitude (3658 m). AMS, oxygen saturation (SpO₂), heart rate (HR), systolic blood pressure(SBP), diastolic blood pressure(DBP), pulmonary artery systolic pressure (PASP) and mean pulmonary arterial pressure (MPAP) were assessed both at 397 m and 3658 m. Results After high-altitude exposure, significantly fewer participants in the baicalin capsules group(n=8, 25.0%) and rhodiola capsules group(n=7, 29.2%) developed acute mountain sickness compared with participants receiving placebo (n=14, 58.3%) (P<0.05) . HR, SBP, DBP, PASP and MPAP increased with altitude exposure (P<0.05), and SpO₂ decreased with altitude exposure (P<0.05). AMS, HR, SBP and DBP with baicalin capsules was lower than those with placebo (P<0.05); AMS, PASP, MPAP with rhodiola capsules were lower than those with placebo (P<0.05) and SpO₂ was higher than that with placebo (P<0.05). Conclusions Baicalin capsules for AMS prevention also reduce HR, SBP and DBP with rapid airlift ascent to high altitude and rhodiola capsules for AMS prevention also reduce PASP, MPAP, increase SpO₂ with rapid airlift ascent to high altitude.

Key words： acute mountain sickness baicalin capsules rhodiola capsules blood pressure pulmonary artery systolic pressure

收稿日期: 2014-07-28

ZTFLH:

R594.3

基金资助:武警部队后勤部2012年科研项目(WJWSB2012-11)

作者简介: 段炜, 硕士, 主任医师

引用本文:

段炜, 孙书红, 惠增骞, 高钊, 胡建库, 金峰, 陈虹. 黄芩苷与红景天胶囊对急性高原病预防作用比较[J]. 武警医学, 2015, 26(1): 75-78. DUAN Wei, SUN Shuhong, HUI Zengqian, GAO Zhao, HU Jianku, JIN Feng, CHEN Hong. Effect of baicalin capsules on acute mountain sickness in healthy young males at acute high altitude exposure. Med. J. Chin. Peop. Armed Poli. Forc., 2015, 26(1): 75-78.

链接本文:

http://journal08.magtechjournal.com/Jwk_wjyx/CN/ 或 http://journal08.magtechjournal.com/Jwk_wjyx/CN/Y2015/V26/I1/75

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[12]	Dean A G, Yip R, Hoffimann R E. High incidence of mild acute mountain sickness in conference attendees at 10, 000 foot altitude [J]. J Wildeness Med, 1990, 1(2):86-92.
[13]	León-Velarde F, Villafuerte F C, Richalet J P. Chronic mountain sickness and the heart [J]. Prog Cardiovasc Dis, 2010, 52: 540-549.
[14]	刘阳, 张继航, 黄岚, 等. 高原暴露人群动脉血压变化与急性高原病的相关性分析[J]. 解放军医学杂志, 2014, 39(3): 226-230.
[15]	王淑琴, 柯国萍, 黄云峰, 等. 长驻高原地区中青年官兵高血压患病率及危险因素分析[J]. 武警医学, 2014, 25(3): 235 -236.
[16]	Hainsworth R, Drinkhill M J, Rivera-Chira M. The autonomic nervous system at high altitude[J]. Clin Auton Res, 2007, 17(1): 13-19.
[17]	傅守廷, 赵乃才. 黄芩甙对儿茶酚胺的拮抗作用[J]. 中国医科大学学报, 1987, 16(6): 176-178.
[18]	付守廷, 付宇. 黄芩苷的耐缺氧作用[J]. 沈阳药科大学学报, 2001, 18(3): 207-209.
[19]	Bhagi S, Srivastava S, Singh S B. High-altitude pulmonary edema [J]. J Occup Health, 2014, 56(4): 235-243.
[20]	Lee S Y, Li M H, Shi LS, et al. Rhodiola crenulata extract alleviates hypoxic pulmonary edema in Rats [J]. Evid Based Complement Alternat Med, 2013, 69(3): 9-12.