Abstract：Objective To investigate the effectiveness and safety of nitrous oxide for colonoscopy and evaluate its clinical application value. Methods A total of 532 patients were randomly divided into N2O group (inhalation with nitrous oxide ) and O2 group (inhalation with pure oxygen).The heart rate(HR) and blood oxygen saturation (SPO2) were observed before, during, and after the colonoscopy. The reaction and feeling of patients and doctors were evaluated by visual analogue scale(VAS). Results There was not significant difference in HR and SPO2 between the N2O group and O2 group. The satisfaction rate of both doctors and patients in the N2O group was higher than O2 group,withsignificant difference(P＜0.01). Conclusions Nitrous oxide for colonoscopy is comfortable and safe, and is worthy of widespread use.
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