Correlation between clopidogrel low response and CYP2C19 gene polymorphism in CAD patients after PCI
SUN Yaqin1,2, YANG Shengli2, YANG Yong2
1.Xinxiang Medical University,Xinxiang 453003, China; 2.Department of Cardiology,the General Hospital of Chiense People’s Armed Police Forces, 100039 Beijing, China
Abstract：Objective To study the correlation between clopidogrel low respone and CYP2C19 gene polymorphism in coronary artery disease(CAD)patients after percutaneous coronary intervention(PCI). Methods A total of 200 patients with CAD admitted to this hospital from October 2013 to October 2014 were included in this study, and treated with dual antiplatelet drugs, aspirin and clopidogrel after PCI. The clopidogrel response was judged by depending on the ADP-induced platelet inhibition rate tested by thromboelastogram (TEG). In this study the ADP-induced platelet inhibition rate less than 30% was defined as clopidogrel low respone and the gene chip detection technology was used to detect the genotyes of CYP2C19 to further explore its effect on clopidogrel respone. Results In these 200 patients, the ADP-induced platelet inhibition rate was statistically significantly different between patients carrying CYP2C19*1/*1 and CYP2C19*1/*2、CYP2C19*1/*1 and CYP2C19*2/*2、extensive and intermediate metabolizers. The total occurrence of clopidogrel low response was 39.5%(79 patients) . There was significant difference between clopidogrel low respone and CYP2C19 genotyes、 metabolizers, indicating that more carriers with extensive metabolizer (CYP2C19*1/*1) in the clopidogrel response group(P=0.013), more carriers with intermediate or poor metabolizers in the clopidogrel low response group(P=0.013). Conclusions There is correlation between clopidogrel low respone and CYP2C19 gene polymorphism in patients with CAD after PCI, more carriers with intermediate or poor metabolizers in the clopidogrel low response group.
孙亚勤, 杨胜利, 杨勇. 冠心病介入术后氯吡格雷低反应性与CYP2C19基因多态性的关系[J]. 武警医学, 2015, 26(6): 580-583.
SUN Yaqin, YANG Shengli, YANG Yong. Correlation between clopidogrel low response and CYP2C19 gene polymorphism in CAD patients after PCI. Med. J. Chin. Peop. Armed Poli. Forc., 2015, 26(6): 580-583.
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2015, Vol. 26 
