Abstract：Objective To compare the quality of cleansing, adverse events, and patient tolerability of four different methods of colon cleansing in preparation for colonoscopy. Methods Three hundred and twenty patients undergoing colonoscopy were randomized into four groups in a prospective, single-blind, controlled trial. Group A received 4 litres of compound polyethylene glycol electrolyte powder (PEG). Group B received 2 litres of PEG plus oral phenolphthalein tablets. Group C received 2 litres of PEG, patients in group D received magnesium sulfate plus phenolphthalein tablets. The quality of cleansing, adverse events and patient tolerability were compared between the four groups. Results Group A and B (90.0%, 88.8%, respectively) showed a significantly greater quality of colon cleansing, compared with groups C and D (73.8%, 67.5%, respectively) (P<0.05). The incidence of adverse events in Group D (42.5%) was significantly higher, compared with group A, B, and C (21.3%, 25.0%, 27.6%, respectively) (P<0.05). A significantly lower tolerability was also observed in group D (75.0%), compared with group A, B, and C (95.0%, 92.5%, 87.5%, respectively) (P<0.05). Conclusions Four litres of PEG and low –volume PEG plus other synergistic laxatives are safe, effective and well tolerated by patients for colon cleansing, and can provide better colon cleansing quality.
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2015, Vol. 26 
