Effect of Wuzhi capsules on pharmacokinetics of tacrolimus
MI Li1,WEI Hua2, LI Jingchao3, QIN Shixin4, and MAO Jianhui1
1.Department of Gastroenterology, 4.Medical Department,Shanghai Municipal Corps Hospital, Chinese People’s Armed Police Force, Shanghai 201103, China; 2.Department of Gastroenterology, Shanghai Changzheng Hospital,Shanghai 200433,China; 3. Medical Department, Hainan Provincial Corps Hospital, Chinese People’s Armed Police Force, Haikou 570203, China
Abstract：Objective To evaluate the effect of different doses of Wuzhi capsules on the pharmacokinatics of Tacrolimus in healthy human body. Methods 40 healthy volunteers were divided into 5 groups, and 0, 1, 2, 6, 8 capsules of Wuzhi capsules were given to each group accordingly after 2 mg of tacrolimus was given systematically. Venous blood was collected before and at different time points after drug administration. Blood samples were collected in anti-coagulation tubes and stored till analysis. Results The dose of tacrolimus was increased with the increase of the dose of Wuzhi capsules AUC0→t, Tmax, and the largest were (459.3±114.2)ng·h/ml and(3.125±1.356)h, respectively, and Cmax was the largest after taking two capsules (43.539±10.656) ng/ml. The CL/F ratio decreased from 51.67% to 27.09% when the dose of Wuzhi capsules increased from 1 capsule to 8 capsules. Conclusions The metabolic rate of tacrolimus decreases, the clearance rate decreases and the blood concentration increases when Wuzhi capsules are administered together with tacrolimus.
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MI Li,WEI Hua, LI Jingchao, QIN Shixin, and MAO Jianhui. Effect of Wuzhi capsules on pharmacokinetics of tacrolimus. Med. J. Chin. Peop. Armed Poli. Forc., 2016, 27(3): 240-242.
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2016, Vol. 27 
