Clinical efficacy of preventing postpartum hemorrhage caused by uterine inertia by using carbetocin
HAN Xiuqin1,LI Rongying1,SUN Yali2,CHENG Yaopin3,and HU Yumei3
1.Department of Gynecology and Obstetrics,Shanxi Provinical Corps Hospital of Chinese People’s Armed Police Force,Taiyuan 030006,China; 2. Department of Radiotherapy,Shanxi Provincial Cancer Hospital,Taiyuan 030003,China; 3.Department of Gynecology and Obstetrics,First Affiliated Hospital of School of Shanxi Province Medicine,Taiyuan 030001,China
Abstract：Objective To study the preventive effect of carbetocin on postpartum hemorrhage. Methods 400 pregnant women of normal term delivery were divided into two groups, 200 cases in vaginal delivery group, 200 in cesarean section group, each group was divided into carbetocin group and oxytocin group. The carbetocin group was given carbetocin 100 μg into the pot after the delivery of the fetus, while for the oxytocin group, oxytocin 10 u was given into the perfusion tube infusion immediately after the delivery of the fetus, 10u into intravenous perfusion lasting for 2 hours after the delivery. The amount of bleeding intrapartum (the surgery) ,within 2 hours and 24 hours after the delivery(after surgery) between the carbetocin group and the oxytocin group was compared. At the same time, the hemoglobin change before the delivery and 24 hours after the delivery was compared. Results 2 h post partum and 24 h postpartum average bleeding volumes in carbetocin vaginal delivery group and cesarean section group were smaller than those in oxytocin vaginal delivery group and cesarean section group:120 ml,poor value respectively at time of delivery, about 45 ml postpartum,about 170 ml 24 hours postpartum.24 h postpartum hemoglobin declining value was also lower than that in carbetocin vaginal delivery group and cesarean sestion group,10 g/L versus and 15 g/L,with significant differences (P<0.05).Conclusion Carbetocin can effectively prevent and reduce postpartum hemorrhage,its effect is significantly higher than that of oxytocin.
Rosseland L A,Hauge T H,Grindheim G,et al.Changes in blood pressure and cardiac output during cesarean Delivery:the effects of oxytocin and carbetocin compared with placebo [J].Anesthesiology,2013,119(3):541-551.
2016, Vol. 27 
