Clinicopathologic features of papillary thyroid carcinoma complicated with asymptomatic parathyroid adenoma
YANG Bo1,LIU Zhiying2,WEN Xiaoju1,and LI Ruiguang1
1.Department of Pathology,Affiliated Tumor Hospital of Xinjiang Medical University,Urumqi 830011,China; 2.Department of Pathology,the Fifth Affiliated Hospital of Xinjiang Medical University,Urumqi 830011,China
Abstract：Objective To improve the diagnosis of parathyroid adenoma by exploring the clinic and pathological manifestations of papillary thyroid carcinoma complicated with asymptomatic parathyroid adenoma.Methods The clinical data and histopathological features of twelve patients who had been diagnosed with PTC and PA in the Affiliated Tumor Hospital to Xinjiang Medical University between January 2005 and December 2014 were retrospectively analyzed.Results Two of the twelve cases suffered from hypercalcemia, increased serum parathyroid hormone(PTH) and hypophosphatemia. Histological examination of PA showed that tumor cells consisted of principal cells and eosinophilic cytoplasm. The tumor cells were nest-like, lamellar or cystic. All of them had intact fibrous capsules. Mitotic figures were rarely encountered and tumor necrosis was absent. Immunohistochemical study showed that the tumor cells in PA were positive(12/12) for CK19, chromogranin A and parathyroid hormone, but were negative for thyroglbulin, TTF-1 and calcitonin. The Ki-67 index was less than 3%.Conclusions The concurrence of PTC and PA is rare.For the coexistence of complex lesions of PA and PTC, preoperative imaging diagnosis is more difficult. Careful preoperative examination is required to rule out the coexistence of the two diseases.
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2017, Vol. 28 
