Therapeutic effects of two insulin delivery systems for patients of gestational diabetes mellitus
JIA Xiaowei1 and LUAN Jin2
1.Department of Endocrinology, Hospital 309 of PLA, Beijing 100091, China; 2.Center for Disease Control and Prevention, Chinese People’s Armed Police Force, Beijing 102613, China
Abstract:Objective To study the difference of therapeutic effects between the insulin pump and direct injection of insulin when used for patients with gestational diabetes mellitus (GDM).Methods 162 patients of gestational diabetes mellitus (GDM) were selected as subjects who were divided into the insulin pump group and the direct injection of insulin group, respectively. The related indicators were monitored by the continuous blood sugar monitoring system and other testing methods when the patients were treated with different therapeutic schemes. The experimental data was analyzed by SPSS 17.0 software.Results After treatment, most indicators of blood glucose, blood lipid and peptide-C in GDM patients were significantly reduced (P<0.05). Moreover,such indicators as peptide-C, HbA1c (%), FPG,2hPG, MAGE and MODD of the insulin pump group were significant lower than those in the direct injection of insulin group after treatment(P<0.05). The relative deviation of indicators was less in the insulin pump group than in the direct injection of insulin group. The insulin pump group had less glycemia variability, but a significantly higher score of quality of life than the direct injection of insulin group(P<0.05).Conclusions The insulin pump has a better therapeutic effect for GDM patients than direct injection of insulin while helping to maintain an ideal level of blood glucose.
贾晓炜,栾 进. 胰岛素两种给药方式对妊娠糖尿病疗效的比较[J]. 武警医学, 2017, 28(5): 483-486.
JIA Xiaowei and LUAN Jin. Therapeutic effects of two insulin delivery systems for patients of gestational diabetes mellitus. Med. J. Chin. Peop. Armed Poli. Forc., 2017, 28(5): 483-486.
Castorino K, Paband R, Zisser H, et al. Insulin pumps in pregnancy: using technology to achieve normoglycemia in women with diabetes[J]. Curr Diab Rep, 2012, 12(1): 53-59.
[2]
Mazze R, Yogev Y, Langer O. Measuring glucose exposure and variability using continuous glucose monitoring in normal and abnormal glucose metabolism in pregnancy[J]. J Matern Fetal Neonatal Med, 2012, 25(7): 1171-1175.
[3]
Sartore G, Chilelli N C, Burlina S, et al. Association between glucose variability as assessed by continuous glucose monitoring (CGM) and diabetic retinopathy in type 1 and type 2 diabetes[J]. Acta diabetol, 2013, 50(3): 437-442.
Kallas-Koeman M M, Kong J M, Klinke J A, et al. Insulin pump use in pregnancy is associated with lower HbA1c without increasing the rate of severe hypoglycaemia or diabetic ketoacidosis in women with type 1 diabetes[J]. Diabetologia, 2014, 57(4): 681-689.
Yu F, Weng J, Lv L et al. Continuous glucose monitoring effects on maternal glycemic control and pregnancy outcomes in patients with gestational diabetes mellitus: a prospective cohort study[J]. J Clin Endocrinol Metab, 2014, 99 (12): 4674.
Su J B, Wang X Q, Chen J F, et al. Glycemic variability in gestational diabetes mellitus and its association with beta cell function[J]. Endocrine, 2013, 43(2): 370-375.
Vejrazkova D, Lukasova P, Vankova M, et al. MTNR1B genetic variability is associated with gestational diabetes in Czech women[J]. Int J Endocrinol, 2014, 57(7): 448.