Abstract：Objective To investigate the role of flurbiprofen axetil in preventing post-ERCP pancreatitis(PEP) in patients after endoscopic retrograde cholangiopancreatography(ERCP).Methods One hundred and ten ASA Ⅰ or Ⅱ patients who had received ERCP were randomly assigned to the group of intravenous injection of 1.5 mg/kg flurbiprofen axetil (flurbiprofen group) and saline alone (placebo group). The serum amylase was detected 6 and 24 h after operation,while the incidence of PEP and postoperative hyperamylasemia was compared between the two groups.Results The serum amylase level in flurbiprofen group was significantly lower than that in control group 6 h and 24 h after ERCP [(225±67.83) U/L vs (379±112.61) U/L,(127±92.77) U/L vs (186±97.28) U/L](P＜0.05). 11.1%(6/54) of the patients in control group had PEP compared with 0.0%(0/56)in flurbiprofen group. 35.19%(19/54) of the patients in control group and 14.9%(8/56)in flurbiprofen group had hyperamylasemia 6 h after ERCP,and the incidence of hyperamylasemia was 20.37%(11/54)in control group and 5.36%(3/56)in flurbiprofen group 24 h after ERCP, so there was significant difference between the two groups(P＜0.05).Conclusions Flurbiprofen axetil is an effective, safe and easy method for prevention of PEP.
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