Abstract：Objective To study adverse drug reactions(ADRs)caused by tetanus antitoxin and provide reference for safe use of drugs in clinic.Methods Literature on ADRs caused by tetanus antitoxin, which was published between January 1996 and October 2016, was retrieved from Wanfang database, CNKI and VIP database with “tetanus antitoxin” and “TAT” as the key words. Related reports were collected and analyzed in terms of age, gender, routes of administration, primary diseases, the time of occurrence of ADRs , human organs or systems involved, allergy history, clinical manifestations and the results.Results A total of 145 pieces of literature, including 158 cases of ADRs caused by tetanus antitoxin, were retrieved. ADRs caused by tetanus antitoxin often occurred among people aged 20 to 39(58.23%). ADRs occurred within 20 min after medication (43.04%), and were mainly manifested as systemic damage (89.24%). Clinical manifestations were mainly allergic shock(46.84%), allergic reaction(39.87%)and serum sickness(2.53%). 98.73% of the cases were improved or cured after symptomatic treatment, but there were two cases(1.27%)of death.Conclusions Doctors should be alert to severe ADRs caused by tetanus antitoxin, such as allergic shock, to ensure drug safety.
2017, Vol. 28 
