1. Department of Nephrology, Shijingshan Teaching Hospital, Capital Medical University, Beijing 100043, China 2. Department of Nephrology, General Hospital of Chinese People’s Armed Police Force, Beijing 100039, China
Abstract：Objective To analyze the changes of serum fibroblast growth factor -23 (FGF-23) and inflammatory factors of secondary hyperparathyroidism (SHPT) patients who had undergone total parathyroidectomy, and explore the significance of these changes.Methods Forty SHPT patients treated with T-PTX between January 2011 and January 2013 in the Department of Nephrology, Armed Police General Hospital, were enrolled in this study. Each patient was given hemodialysis. Serum FGF -23, parathyroid hormone (PTH), calcium(Ca), phosphorus (P) and high sensitivity reactive protein (hsCRP) obtained during the preoperative, postoperative and follow-up periods were collected and compared.Results (1)Serum levels of FGF-23, PTH, Ca, P, and hsCRP decreased significantly one day, one month, three months and 6 months after PTX (P＜0.05). (2)Levels of serum hsCRP decreased one day after PTX, but not significantly. Serum hsCRP was (20.31±8.56)mg/L before PTX, and was (11.72±5.21) mg/L, (2.64±1.32) mg/L, and (2.16±1.08)mg/L respectively 1 month, 3 months, and 6 months after PTX (P＜0.05).Conclusions T-PTX can effectively reduce the levels of serum FGF-23, PTH and inflammatory factors, correct the disturbance of Ca and P metabolism, and reduce the incidence of long-term cardiovascular events and bone metabolism diseases.
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2017, Vol. 28 
