Abstract：Objective To investigate the feasibility of vein patch grafts being used to repair defective tracheal membranous walls.Methods The right jugular veins of eight adults dogs were harvested though midline cervical incisions and used as patch grafts. Each cervical trachea was exposed and a full-thickness lesion (2 cm×2 cm) was created in the cervical tracheal membranous wall by resecting part of the trachea at the forth ring below the cricoid cartilage. The defect was repaired by grafting a vein patch to the posterior surface of the injured part.Results All the eight dogs survived without complications until euthanasia 6 months later. Bronchoscopic examination demonstrated adequate tracheal patency with no inspiratory or expiratory collapse. The experimental dogs were killed 6 months after operation, and the constrictive ratio of the cross-sectional area of the most stenotic site to that of the third tracheal ring below the membranous patch was 1.07±0.04, suggesting that there was no obvious stenosis in the tracheal lumen. Histological examination revealed neoepithelium on the surfaces of all the patch grafts.Conclusions Our Results indicate that jugular vein patch grafts can be effectively and safely used to repair tracheal membranous wall lesions.
曹磊, 曹智理, 李单青. 游离自体静脉补片修复实验犬气管膜部缺损的可行性[J]. 武警医学, 2017, 28(12): 1232-1235.
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