Abstract：Objective To investigate the efficacy of flurbiprofenaxetil combined with dezocine during gallbladder removal surgery. Methods One hundred patients of ASAⅠ－Ⅱ undergoing gallbladder removal surgery were randomly assigned to four groups(n=25):flurbiprofenaxetil group, dezocine group, flurbiprofenaxetil combined with dezocine group and control group. Before anesthesia induction, flurbiprofenaxetil 1.5 mg/kg was injected intravenously in flurbiprofenaxetil group， dezocine 0.15 mg/kg in dezocine group, flurbiprofenaxetil 1.5 mg/kg combined with dezocine 0.15 mg/kg in flurbiprofenaxetil combined with dezocine group,while an equal volume of saline was given in control group. The extubation time and visual analgesia scale scores were recorded at 2,4,6,12 and 24 h after operation.The incidence of adverse reactions was recorded within 24 h. Results The VAS scores at 2,4,and 6 h were lower in flurbiprofenaxetil group and dezocine group than in control group (P<0.05), and were lower in flurbiprofenaxetil combined with dezocine group than in control group at 2,4,6 and 12 h (P<0.05). Compared with control group, the incidence of complications was increased in the other three groups (P<0.05). Compared with flurbiprofenaxetil combined with dezocine group, the incidence of dizziness and somnolence was decreased in flurbiprofenaxetil group(P<0.05), and that of nausea was decreased in dezocine group(P<0.05). Conclusions Flurbiprofenaxetil (1.5 mg/kg) combined with dezocine has (0.15 mg/kg）better analgesic effect, but the adverse reaction rate can increase in patients during gallbladder removal surgery.
Kehl H. Acute pain control and accelerated postoperative surgical recovery [J] . Surg Clin North Am ，1999,79（2）:431-443.
[2]
Eriksson H, Tenhunen A, Korttila K, et al. Balanced analgesia improves recovery and outcome after outpatient tubal ligation [J] .Acta Anaesthesiol Scand，1996,40（2）: 151-155.
[3]
Michaloliakou C , Chung F, Sharma S, et al. Preoperative multimodal analgesia facilit ates recovery after ambulatory laparoscopic cholecystectomy[J]. Anesth Analg，1996,82（1）:44-51.
[4]
Pavlin D J, Horvath K D, Pavlin E G, et al. Preincision treatment to prvent pain after ambulatory hernia surgery[J]. Anesth Analg，2003,97（6）:1627-1632.
[5]
Dahl J U,Moiniche S.Pre-emptive analgesia[J] .Br Med Bull,2004, 13(4):71 .
[6]
Ong C K, Lirk P, Seymour R A, et al. The efficacy of preemptive analgesiafor acute postoperative pain management: a meta-analysis[J]. Anesth Analg,2005,100(3):757-773.
[7]
Mizuno J,Sugimoto S,Kaneko A, et al. Convulsion following the combination of single preoperative oral administration of enoxacine and single post operative intrave nous administration of flurbiprofen axetil[J]. Jpn Anesth，2001, 50（4）:425-428.
[8]
Takada M，Fukusaki M，Terao Y，et al. Pread-Ministrationof flurbiprofen suppresses prostraglandin production and postoperativepain in orthopedic patients undergoing tourniquet inflation [J].Clin Anesth,2007,19(2):97.
[9]
Roms ing J, Moiniche S, Ostergaard D, et al. Local in filtration with NSAIDs for postoperative analgesia: evidence for a peripheral analgesic action [J]. Acta Anaesth esiol Scand，2000，44（6）:672-683.
[10]
Kelly D J，Ahmad M，Brull S J, et al. Preemptive analgesia I: physiological pathways and pharmacological modalities [J]. Can J Anesth，2001，48(10):1000.
[11]
Ochroch E A，Mardini Z A，Gottschalk A, et al. What is the rolo of NSAIDs in preemptive analgesia? [J]. Drugs,2003,63(24) : 2709.
[12]
Sibille K T,Kindler L L,Glover T L, et al. individualdifferences in morphine and but orphanol analgesia:a laboratory pain study[J]. Pain Med,2011,12(7):1076-1085.
[13]
Kehlet H, Wilmore D W. Multimodal strategies to improve surgical outcome[J]. Am J Surg 2002,183(6):630-641.
[14]
Ong C K，Lirk P，Seymour Ｒ A， et al. The efficacy of preemptive analgesia for acute postoperative pain management: a meta-analysis[J].Anesth Analg，2005，100（3）: 757-773.
2018, Vol. 29 
