Abstract：Objective To investigate the factors associated with axSpA in soldiers of People's Armed Police Force.Methods Eighty-seven soldiers with axSpA were recruited between 2010 and 2017 while another 102 soldiers diagnosed with non-rheumatic chronic musculoskeletal pain during the same period were assigned as control group.Factors associated with axSpA, including age,length of military service,rank,types of work,history of the family,history of smoking and genetic factors, were analyzed in the study.Results The various factors were analyzed with chi-square and single factor logistic regression analysis.It was found that age,history of smoking,types of work and genetic backgrounds were statistically significant for the incidence of axSpA.Multivariate logistic regression analysis showed that age,types of work and genetic backgrounds were risk factors for axSpA.Conclusions In addition to AS,there is a considerable number of nr-axSpA patients in the Armed Police Force.The genetic background is a major risk factor for axSpA,and the types of work are closely related to the onset of axSpA.
Smith J A, Märker-Hermann E, Colbert R A. Pathogenesis of ankylosing spondylitis: current concepts[J]. Best Pract Res Clin Rheumatol, 2006,20(3):571-591.
[2]
Weber U, Zubler V, Zhao Z, et al . Does spinal MRI add incremental diagnostic value to MRI of the sacroiliac joints alone in patients with non-radiographic axial spondyloarthritis?[J]. Annals of the Rheumatic Diseases, 2015, 74(6):985-992.
[3]
Moll J M, Wright V. Psoriatic arthritis[J]. Semin Arthritis Rheum, 1973,3(1):55-78.
[4]
Sieper J, van der Heijde D. Review: Nonradiographic axial spondyloarthritis: new definition of an old disease?[J]. Arthritis Rheum, 2013,65(3):543-551.
[5]
Ward M M, Learch T J, Gensler L S, et al . Regional radiographic damage and functional limitations in patients with ankylosing spondylitis: differences in early and late disease[J]. Arthritis Care Res (Hoboken), 2013,65(2):257-265.
[6]
Maksymowych W P. Spondyloarthritis in 2012: Advances in pathogenesis through animal models and imaging[J]. Nat Rev Rheumatol, 2013,9(2):72-74.
Tarner I H, Müller-Ladner U, Uhlemann C, et al . The effect of mild whole-body hyperthermia on systemic levels of TNF-alpha, IL-1beta, and IL-6 in patients with ankylosing spondylitis[J]. Clin Rheumatol, 2009,28(4):397-402.
Kiltz U, Baraliakos X, Karakostas P, et al . Do patients with non-radiographic axial spondylarthritis differ from patients with ankylosing spondylitis?[J]. Arthritis Care Res (Hoboken), 2012,64(9):1415-1422.
[16]
Poddubnyy D, Rudwaleit M, Haibel H, et al . Rates and predictors of radiographic sacroiliitis progression over 2 years in patients with axial spondyloarthritis[J]. Ann Rheum Dis, 2011,70(8):1369-1374.
Chung H Y, Machado P, van der Heijde D, et al . Smokers in early axial spondyloarthritis have earlier disease onset, more disease activity, inflammation and damage, and poorer function and health-related quality of life: results from the DESIR cohort[J]. Ann Rheum Dis, 2012,71(6):809-816.
[19]
Callhoff J,Sieper J, Wei A, et al . Efficacy of TNFα blockers in patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis: a meta-analysis[J]. Annals of the Rheumatic Diseases, 2015, 74(6):1241-1248.
2018, Vol. 29 
