Friedenstein A J, Piatetzky-Shapiro I I, Petrakova K V. Osteogenesis in transplants of bone marrow cells[J]. J Embryol Exp Morphol, 1966,16(3):381-390.
[2]
Caplan A I. Mesenchymal stem cells[J]. J Orthop Res, 1991,9(5):641-650.
[3]
Pittenger M F, Mackay A M, Beck S C, et al . Multilineage potential of adult human mesenchymal stem cells[J]. Science, 1999,284(5411):143-147.
Carreira A C, Zambuzzi W F, Rossi M C, et al . Bone Morphogenetic Proteins: Promising Molecules for Bone Healing, Bioengineering, and Regenerative Medicine[J]. Vitam Horm, 2015,99:293-322.
[8]
Kim Y J, Bae S W, Yu S S, et al . miR-196a regulates proliferation and osteogenic differentiation in mesenchymal stem cells derived from human adipose tissue[J]. J Bone Miner Res, 2009,24(5):816-825.
[9]
Liao Y H, Chang Y H, Sung L Y, et al . Osteogenic differentiation of adipose-derived stem cells and calvarial defect repair using baculovirus-mediated co-expression of BMP-2 and miR-148b[J]. Biomaterials, 2014,35(18):4901-4910.
[10]
Huang S, Wang S, Bian C, et al . Upregulation of miR-22 promotes osteogenic differentiation and inhibits adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells by repressing HDAC6 protein expression[J]. Stem Cells Dev, 2012,21(13):2531-2540.
[11]
Suh J S, Lee J Y, Choi Y S, et al . Peptide-mediated intracellular delivery of miRNA-29b for osteogenic stem cell differentiation[J]. Biomaterials, 2013,34(17):4347-4359.
[12]
Wang Q, Cai J, Cai X H, et al . miR-346 regulates osteogenic differentiation of human bone marrow-derived mesenchymal stem cells by targeting the Wnt/beta-catenin pathway[J]. PLoS One, 2013,8(9):e72266.
[13]
Meng Y B, Li X, Li Z Y, et al . microRNA-21 promotes osteogenic differentiation of mesenchymal stem cells by the PI3K/beta-catenin pathway[J]. J Orthop Res, 2015,33(7):957-964.
[14]
Song B Q, Chi Y, Li X, et al . Inhibition of Notch Signaling Promotes the Adipogenic Differentiation of Mesenchymal Stem Cells Through Autophagy Activation and PTEN-PI3K/AKT/mTOR Pathway[J]. Cell Physiol Biochem, 2015,36(5):1991-2002.
Sun F, Wan M, Xu X, et al . Crosstalk between miR-34a and Notch Signaling Promotes Differentiation in Apical?Papilla Stem Cells (SCAPs)[J]. J Dent Res, 2014,93(6):589-595.
[17]
Luo H, Gao H, Liu F, et al . Regulation of Runx2 by microRNA-9 and microRNA-10 modulates the osteogenic differentiation of mesenchymal stem cells[J]. Int J Mol Med, 2017,39(4):1046-1052.
[18]
Gamez B, Rodriguez C E, Bartrons R, et al . MicroRNA-322 (miR-322) and its target protein Tob2 modulate Osterix (Osx) mRNA stability[J]. J Biol Chem, 2013,288(20):14264-14275.
[19]
Jeong B C, Kang I H, Hwang Y C, et al . MicroRNA-194 reciprocally stimulates osteogenesis and inhibits adipogenesis via regulating COUP-TFII expression[J]. Cell Death Dis, 2014,5:1532.
[20]
Li J, Dong J, Zhang Z H, et al . miR-10a restores human mesenchymal stem cell differentiation by repressing KLF4[J]. J Cell Physiol, 2013,228(12):2324-2336.
[21]
Yang N, Wang G, Hu C, et al . Tumor necrosis factor alpha suppresses the mesenchymal stem cell osteogenesis promoter miR-21 in estrogen deficiency-induced osteoporosis[J]. J Bone Miner Res, 2013,28(3):559-573.
[22]
Zhang W B, Zhong W J, Wang L. A signal-amplification circuit between miR-218 and Wnt/beta-catenin signal promotes human adipose tissue-derived stem cells osteogenic differentiation[J]. Bone, 2014,58:59-66.
[23]
Yang M, Pan Y, Zhou Y. miR-96 promotes osteogenic differentiation by suppressing HBEGF-EGFR signaling in osteoblastic cells[J]. FEBS Lett, 2014,588(24):4761-4768.
[24]
Kureel J, Dixit M, Tyagi A M, et al . miR-542-3p suppresses osteoblast cell proliferation and differentiation, targets BMP-7 signaling and inhibits bone formation[J]. Cell Death Dis, 2014,5:1050.
[25]
Gu Y, Ma L, Song L, et al . miR-155 Inhibits Mouse Osteoblast Differentiation by Suppressing SMAD5 Expression[J]. Biomed Res Int, 2017,2017:1893520.
[26]
Wang J, Guan X, Guo F, et al . miR-30e reciprocally regulates the differentiation of adipocytes and osteoblasts by directly targeting low-density lipoprotein receptor-related protein 6[J]. Cell Death Dis, 2013,4:e845.
[27]
Li T, Li H, Wang Y, et al . microRNA-23a inhibits osteogenic differentiation of human bone marrow-derived mesenchymal stem cells by targeting LRP5[J]. Int J Biochem Cell Biol, 2016,72:55-62.
[28]
Wang Y, Chen S, Deng C, et al . MicroRNA-204 Targets Runx2 to Attenuate BMP-2-induced Osteoblast Differentiation of Human Aortic Valve Interstitial Cells[J]. J Cardiovasc Pharmacol, 2015,66(1):63-71.
[29]
Yang M, Pan Y, Zhou Y. miR-96 promotes osteogenic differentiation by suppressing HBEGF-EGFR signaling in osteoblastic cells[J]. FEBS Lett, 2014,588(24):4761-4768.
[30]
Lv H, Sun Y, Zhang Y. MiR-133 is Involved in Estrogen Deficiency-Induced Osteoporosis through Modulating Osteogenic Differentiation of Mesenchymal Stem Cells[J]. Med Sci Monit, 2015,21:1527-1534.
[31]
Weilner S, Schraml E, Wieser M, et al . Secreted microvesicular miR-31 inhibits osteogenic differentiation of mesenchymal stem cells[J]. Aging Cell, 2016,15(4):744-754.
[32]
Schoolmeesters A, Eklund T, Leake D, et al . Functional profiling reveals critical role for miRNA in differentiation of human mesenchymal stem cells[J]. PLoS One, 2009,4(5):5605.
[33]
Wang H, Xie Z, Hou T, et al . MiR-125b Regulates the Osteogenic Differentiation of Human Mesenchymal Stem Cells by Targeting BMPR1b[J]. Cell Physiol Biochem, 2017,41(2):530-542.
[34]
Kim E J, Kang I H, Lee J W, et al . MiR-433 mediates ERRgamma-suppressed osteoblast differentiation via direct targeting to Runx2 mRNA in C3H10T1/2 cells[J]. Life Sci, 2013,92(10):562-568.
2018, Vol. 29 
