Abstract：Objective To explore the effect of dexmetomidine on postoperative delirium in elderly patients with hip fracture.Methods One hundred and thirty-six postoperative patients with hip fracture and above 65 years old were randomly divided into 2 groups:dexmedetomidine group(n=69)and normal group (n=67).In dexmedetomidine group, the patients received dexmedetomidine by intravenous continuous infusion at 0.2 μg/(kg·h) within 20 minutes of their admission to the ICU.PCIA、VAS pain scores、 Ramsay sedation scores and the incidence of deliriumu were recorded at different time points after surgery.CAM-ICU was used to diagnose delirium.Results The total number of presses by PCIA, number of effective presses, drug consumption, SPO2 and postoperative pain scores of these patients were not significantly different upon their admission to the ICU, 6 h and 12 h after surgery(P>0.05). Heart rate and MAP in the dexmedetomidine group were lower than in the normal group, but sedation scores were higher at the same time point and 6 h and 12 h after admission to the ICU. CRP was lower and hours of sleep were longer in the dexmedetomidine group than in the normal group. There were 7 cases of postoperative delirium (10.14%)in the dexmedetomidine group, but 20 cases (29.85%)in the normal group 12 hours after surgery. The difference between the two groups was statistically significant (P<0.05).Conclusions Continuous intravenous infusion of dexmetomidine can reduce the incidence of postoperative delirium in elder patients with hip fracture.
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