Effect of dexmedetomidine combined with butorphanol on sedation and analgesia in patients undergoing mechanical ventilation after abdominal surgery
GUI Chunmei1, LIU Sen2
1.ICU, the First People’s Hospital of Changde, Changde 415000, China; 2. The Inner Mongolia Autonomous Region Corps Hospital of Chinese People’s Armed Police Force, Hohhot 010040, China
Abstract：Objective To explore the effect of dexmedetomidine combined with butorphanol on sedation and analgesia in patients undergoing mechanical ventilation after abdominal surgery.Methods A total of 60 patients admitted to ICU to undergo mechanical ventilation after abdominal surgery were randomly divided into control group and treatment group, with 30 patients in each. For sedation and analgesia, the control group was given midazolam and fentanyl, while the treatment group received dexmedetomidine plus butorphanol. Such vital signs as heart rate (HR), respiratory rate (RR), mean arterial pressure (MAP), and blood oxygen saturation (SpO2) before medication and 1 h after medication were compared between the two groups. Critical Care Pain Observation Tool (CPOT) scores and Richmond Agitation Sedation Scale scores (RASS) at 4, 8, 16 and 24 h were observed. Meanwhile, drug onset time, extubation time, total awake time after drug discontinuation, incidence of adverse reactions, and delirium were compared.Results ①At 1 h after administration, HR, RR, and MAP in both groups were significantly lower (P<0.05). ②There was no significant difference in CPOT or RASS scores at 4, 8, 16 and 24 h after treatment in either group. ③No significant difference in drug onset time was seen between the two groups, but extubation time and total awake time after drug discontinuation in the treatment group were (112.3±18.6) and (43.8±7.6)min, respectively, which were significantly shorter than(175.1±20.4), (116.2±27.3)min, respectively, in the control group (P<0.01). ④ The incidence of hypotension and bradycardia was not significantly different between the two groups, but the incidence of abdominal distension, vomiting and delirium in the treatment group was significantly lower than in the control group (P<0.05).Conclusions Dexmedetomidine combined with butorphanol has similar efficacy to midazolam combined with fentanyl on sedation and analgesia of patients undergoing mechanical ventilation after abdominal surgery, but has lower incidence of delirium, abdominal distension and vomiting, and is safer for patients.
贵春梅, 刘森. 右美托咪啶联合布托啡诺对腹部外科术后机械通气患者镇静镇痛的效果[J]. 武警医学, 2018, 29(11): 1065-1068.
GUI Chunmei, LIU Sen. Effect of dexmedetomidine combined with butorphanol on sedation and analgesia in patients undergoing mechanical ventilation after abdominal surgery. Med. J. Chin. Peop. Armed Poli. Forc., 2018, 29(11): 1065-1068.
2018, Vol. 29 
