Diagnostic value of serum ferritin in patients diagnosed with multiple myeloma
WU Xiaoying1,2,YU Qing1,and TAO Yi1
1.Department of Emergency, Shanghai Armed Police Hospital, Shanghai 201103, China; 2. Department of Hematology, the Tenth People’s Hospital of Tongji University, Shanghai 200072,China
Abstract：Objective To analyze the clinical significance of serum ferritin (SF) in patients who were diagnosed with multiple myeloma (MM).Methods Thirty-two newly-diagnosed MM patients treated in the Department of Hematology of Shanghai Tenth Hospital between January 2016 and June 2018 were enrolled in the MM group, while another 39 healthy volunteers were assigned to the normal control group in the same period of time. Other factors that could increase levels of SF were excluded in the MM group. The levels of SF of the two groups were detected to find out whether there was statistically significant difference between the two groups. The diagnostic value of SF in MM patients was determined by the ROC curve. SF levels and related levels of β2-microglobulin (β2-MG) and lactate dehydrogenase (LDH) before each cycle of chemotherapy in the MM group were followed up totally for 169 person-times, and statistical analysis was performed. The value of SF at different stages of MM patients was further analyzed.Results The levels of SF in the 32 patients with MM (546.60±427.66) ng/ml were significantly higher than those of normal controls (231.20±111.70)ng/ml (P=0.000). In the ROC curve analysis, the area under the SF level curve was 0.75 (P=0.000), which was of diagnostic significance. According to the levels of SF, β2-MG and LDH in MM patients before each cycle of chemotherapy, it was found that there was a positive correlation between SF levels and β2-MG levels (r=0.714, P<0.01), but no significant correlation with LDH levels (r=0.059, P>0.05). SF levels in stage Ⅲ MM patients were significantly higher than those in stage Ⅰ and stage Ⅱ MM patients (P<0.05).Conclusions SF is of diagnostic value for MM, which can reflect tumor burden to some extent. SF combined with β2-MG can facilitate staging and prognosis of multiple myeloma.
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2018, Vol. 29 
