Abstract：Objective To analyze the therapeutic effect of GnRH-a combined with desogestrel and ethinylestradiol against endometriosis and the effect on endocrine hormone and pregnancy.Methods Sixty-four patients with endometriosis diagnosed in our hospital between August 2016 and February 2018 were randomly divided into the study group (n=32) and the control group (n=32). All the patients underwent laparoscopic surgery. The control group was treated with desogestrel and ethinylestradiol, while the study group received GnRH-a combined with desogestrel and ethinylestradiol. The therapeutic effects were compared between the two groups.Results The levels of LH, FSH and E2 in the study group were (2.05±0.43)mmol/L, (4.36±0.52) mmol/L and (15.37±2.46)pg/mL respectively, all of which were better than those of the control group (P<0.05). The scores of pelvic pain, dysmenorrhea and dyspareunia were (0.38±0.11), (2.38±0.62) and (0.08±0.02) points in the study group, lower than in the control group (P<0.05). The recovery time of the menstrual cycle and the time taken by the menstrual blood volume to return to normal was (86.21±8.04)d and (54.56±5.42)d in the study group, both of which were shorter than in the control group (P<0.05). The pregnancy rate (59.38%), recurrence rate, and incidence of adverse reactions (12.50%) in the study group compared favorably with the control group (P<0.05).Conclusions For recipients of laparoscopic surgery for endometriosis, GnRH-a combined with desogestrel and ethinylestradiol is quite effective, which can help reduce the level of endocrine hormone, improve clinical symptoms and pregnancy rate, induce fewer adverse reactions or cases of recurrence.
王丽华,徐景杰,张嫱. 子宫内膜异位症腹腔镜术后应用促性腺激素释放激素激动药联合去氧孕烯炔雌醇的疗效[J]. 武警医学, 2019, 30(3): 189-192.
WANG Lihua,XU Jingjie, ZHANG Qiang. Clinical effect of Gnrh-A assisted laparoscopic surgery for endometriosis and its effects on endocrine hormone and pregnanc. Med. J. Chin. Peop. Armed Poli. Forc., 2019, 30(3): 189-192.
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2019, Vol. 30 
