老年慢性心力衰竭患者血浆CTGF、iPTH、甲状腺激素水平与心功能的相关性

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摘要目的探讨老年慢性心力衰(chronic heart failure,CHF)竭患者血浆CTGF、iPTH、甲状腺激素、NT-proBNP及LVMI与心功能的相关性。方法选取≥60岁CHF患者120例,分为心功能Ⅱ级、Ⅲ级、Ⅳ级组,各40例;选取同期住院体检的健康老人40例作为对照组。比较四组血浆CTGF、iPTH、甲状腺激素水平、NT-proBNP及LVMI的差异,采用Spearman等级相关分析CHF患者血浆CTGF、iPTH、甲状腺激素水平、NT-proBNP、LVMI与心功能分级的相关性。结果 CHF心功能Ⅱ级组、Ⅲ级组、Ⅳ级组血浆CTGF、iPTH、NT-proBNP、LVMI水平明显高于对照组(P＜0.01),且随心功能分级的升高,血浆CTGF、iPTH、NT-proBNP、LVMI水平明显升高 (P＜0.05);心功能Ⅱ、Ⅲ、Ⅳ级三组患者FT3水平明显均低于对照组(P＜0.01),且随心功能分级的升高,FT3水平明显降低 (P＜0.05)。血浆CTGF、iPTH、NT-proBNP、LVMI与心功能分级呈正相关(ρ>0.6,P＜0.05);FT3与心功能分级呈负相关 (ρ<-0.6,P＜0.05)。CHF患者血浆CTGF、NT-proBNP、iPTH均与LVMI呈正相关(r>0.6, P＜0.05);FT3与LVMI呈负相关(r<-0.6, P＜0.05)。结论血浆CTGF、iPTH、FT3、NT-proBNP及LVMI与老年CHF患者心功能分级相关性较强,可作为CHF临床诊断和病情评估的重要指标。

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	文芳梅
	程新春

关键词 ：慢性心力衰竭, CTGF, iPTH, 甲状腺激素, 心功能

Abstract：Objective To investigate the values of plasma CTGF, iPTH, thyroid hormones,NT-proBNP, and LVMI in elderly patients with chronic heart failure and their correlations with cardiac function. Methods A total of 120 cases of elderly patients with chronic heart failure treated in our hospital between June 2016 and December 2017 were selected as the case group, whose plasma CTGF, iPTH, thyroid hormones, NT-proBNP and LVMI were detected.According to the NYHA cardiac function classification standard, these patients were divided into grade Ⅱ, Ⅲ,and Ⅳ groups, with 40 cases in each. Another 40 healthy elderly patients treated in the same period were selected as the control group.The levels of plasma CTGF, iPTH, thyroid hormones,NT-proBNP and LVMI were compared between the four groups. Spearman correlation was used to analyze the correlations between plasma CTGF, iPTH, thyroid hormones, NT-proBNP, LVMI and cardiac function grading in patients with chronic heart failure. Results ①The levels of plasma CTGF, iPTH, NT-proBNP and LVMI in grade Ⅱ, Ⅲ and Ⅳ groups were significantly higher than those in the control group (P＜0.01). These levels increased with the grade. The difference was statistically significant (P＜0.05).②The level of FT3 in grade Ⅱ, Ⅲ and Ⅳ groups was significantly lower than that in the control group (P＜0.01),which decreased with the grade, and the difference was statistically significant (P＜0.05).③The results of Spearman correlation analysis indicated that there was a positive correlation between plasma CTGF, iPTH, NT-proBNP,LVMI and cardiac function grading (ρ>0.6,P＜0.05). FT3 was negatively correlated with cardiac function grading (ρ>-0.6,P＜0.05).④ The results of Pearson correlation analysis showed that plasma CTGF, iPTH,NT-proBNP and LVMI were positively correlated (r>0.6,P＜0.05). FT3 was negatively correlated with LVMI (r<-0.6,P＜0.05). Conclusions Plasma CTGF, iPTH, FT3, NT-proBNP and LVMI are strongly correlated with cardiac function grading in elderly patients with chronic heart failure, which can be used as important indicators for clinical diagnosis and condition evaluation of chronic heart failure.

Key words： chronic heart failure CTGF iPTH thyroid hormone cardiac function

收稿日期: 2018-12-20

ZTFLH:

R541.61

基金资助:新疆维吾尔自治区人民医院院内科研项目(20150313)

作者简介: 文芳梅,硕士,主任医师。

引用本文:

文芳梅, 程新春. 老年慢性心力衰竭患者血浆CTGF、iPTH、甲状腺激素水平与心功能的相关性[J]. 武警医学, 2019, 30(4): 299-302. WEN Fangmei, CHENG Xinchun. Plasma CTGF, iPTH and thyroid hormones in elderly patients with chronic heart failure. Med. J. Chin. Peop. Armed Poli. Forc., 2019, 30(4): 299-302.

链接本文:

http://journal08.magtechjournal.com/Jwk_wjyx/CN/ 或 http://journal08.magtechjournal.com/Jwk_wjyx/CN/Y2019/V30/I4/299

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