复方丹参滴丸对新发2 型糖尿病患者视网膜的影响

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摘要目的探讨复方丹参滴丸对新发2型糖尿病患者视网膜病变(diabetic retinopathy, DR)的影响。方法选取2010年1－8月医院门诊和住院新发2型糖尿病患者72例,入组前均未诊治。随访7年。随机分为对照组(34例)和观察组(38例)。对照组采用糖尿病常规治疗,观察组在常规治疗6周后口服复方丹参滴丸。比较治疗期间视网膜发生变化情况,并比较空腹血糖(FPG)、糖化血红蛋白(hemoglobin A1c, HbA1c)、血脂、血压等指标。结果 (1)两组患者治疗后TC与本组治疗前比较,差异均有统计学意义(P<0.05);观察组治疗5年后低于治疗前,治疗7年后又高于治疗5年后,差异均有统计学意义(P<0.05);两组患者治疗后与本组治疗前HDL-C比较,差异均有统计学意义(P<0.05);对照组TG治疗后7年略有升高,而观察组TG治疗5年、7年后均有降低,且两组与治疗前比较差异均有统计学意义。两组治疗前、治疗7年后的FPG、HbA₁c、血压同期比较均无统计学差异。(2)两组DR发生率均逐渐增高,治疗7年后观察组发生率(9.6%)低于对照组(32.14%),两组比较差异有统计学意义(P<0.05)。(3)对照组患者治疗7年后与本组治疗5年后比较DR发生率有统计学差异(P<0.05),而观察组治疗前后均无统计学意义。结论复方丹参滴丸治疗可延缓DR的发生及发展。

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	史保权
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	沈勇
	王锐

关键词 ： 2型糖尿病, 复方丹参滴丸, 视网膜

Abstract：Objective To observe the effect of Compound Danshen Dropping Pills on retinopathy in newly diagnosed patients with type 2 diabetes mellitus.Methods Between January and August 2010, 72 outpatients and inpatients were selected, who received no diagnosis or treatment before being grouped. The follow-up lasted seven years.They were randomly divided into two groups: control group (34 cases) and observation group (38 cases). The control group received routine treatment of diabetes mellitus, while the observation group was treated with Compound Danshen Dropping Pills after six weeks of routine treatment.The changes of retinas during treatment were compared, and the relationships between fasting blood glucose, glycosylated hemoglobin, blood lipid and blood pressure were studied.Results (1) The change of TC in the two groups after treatment was statistically significant (P<0.05). LDL-C in the observation group was significantly different after treatment (P<0.05). After treatment, HDL-C of the two groups was significantly higher (P<0.05). In the control group increased slightly after 7 years of TG treatment, but decreased in the observation group after 5 and 7 years of TG treatment, and the difference between the two groups was statistically significant. However, there was no significant difference in FPG, HbA1c or blood pressure between the two groups before treatment and 7 years after treatment. (2) The incidence of DR in both groups increased gradually. After 7 years of treatment, the incidence in the observation group (9.6%) was lower than that in the control group (32.14%), so there was statistically significant difference between the two groups (P<0.05). 3) The incidence of DR in the control group after 7 years of treatment was significantly different from that in the control group after 5 years of treatment (P<0.05), but there was no statistically significant change in the observation group before and after treatment.Conclusions Compound Danshen Dropping Pills can delay the occurrence and development of DR.

Key words： type 2 diabetes mellitus Compound Danshen Dropping Pills retina

收稿日期: 2019-03-10

ZTFLH:

R587.2

通讯作者: 李艳,E-mail:liyan789@163.com

作者简介: 史保权,本科学历,副主任药师。

引用本文:

史保权,马荣炜,刘彩霞,王培,刘苔,沈勇,王锐. 复方丹参滴丸对新发2 型糖尿病患者视网膜的影响[J]. 武警医学, 2019, 30(8): 680-683. SHI Baoquan, MA Rongwei, LIU Caixia, WANG Pei, LIU Tai, SHEN Yong, and WANG Rui. Effect of Compound Danshen Dropping Pills on retinas of patients with new type 2 diabetes mellitus. Med. J. Chin. Peop. Armed Poli. Forc., 2019, 30(8): 680-683.

链接本文:

http://journal08.magtechjournal.com/Jwk_wjyx/CN/ 或 http://journal08.magtechjournal.com/Jwk_wjyx/CN/Y2019/V30/I8/680

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