Changes of serum IL-18, sICAM-1 and IGF-1 in patients with cerebral infarction treated with Cinepazide Maleate and Danshen Ligustrazine injection
GUO Xiaoying1, SUN Changyou1, GAO Li2, MA Biao3
1.Department of Pharmacy,2.Depatment of Cardiology,3.Department of Hematology,Shanxi Provincial Corps Hospital, Chinese People’s Armed Police Force, Taiyuan 030006, China
Abstract：ObjectiveTo investigate the therapeutic effect of Cinepazide Maleate combined with Danshen Ligustrazine injection against cerebral infarction by observing changes in serum interleukin (IL)-18, soluble intercellular adhesion molecule (sICAM)-1, and insulin-like growth(IGF)-1 in patients.Methods One hundred and thirty-five cases of patients with cerebral infarction who were treated in our hospital between September 2015 and December 2018 were selected and divided into the control group(n=65) and the combination group(n=70) according to treatment methods. The control group was treated with Cinepazide Maleate, while the combination group was additionally treated with Danshen Ligustrazine injection. Both groups were treated for 3 months, and the levels of serum IL-18, sICAM-1 and IGF-1 were detected and recorded.Results All the patients completed the treatment and no serious adverse reactions occurred during the treatment. The total effective rate of the combination group was 97.1%, which was significantly higher than that of the control group (86.2%) (P<0.05). The MoCA scores, cranial vertebral artery and basilar artery blood flow velocity in the two groups were significantly higher after treatment (P<0.05), especially in the combination group (P<0.05). The levels of serum IL-18, sICAM-1 and IGF-1 in the two groups were significantly lower after treatment (P<0.05), particularly in the combination group (P<0.05).Conclusions Cinepazide Maleate combined with Danshen Ligustrazine injection, when used in the treatment of cerebral infarction, can inhibit the expressions of serum IL-18, sICAM-1 and IGF-1, boost the cerebral blood flow and improve the cognitive function and overall therapeutic effect.
Guo Y E, Togher L, Power E, et al. Validation of the stroke and aphasia quality of life scale in a multicultural population[J]. Disabil Rehabil, 2016, 38(26): 2584-2592.
[2]
Lin H F, Chern C M, Chen H M, et al. Validation of NINDS-VCI neuropsychology protocols for vascular cognitive impairment in Taiwan[J]. PLoS One, 2016, 11(6): e0156404.
[3]
Mou Z, Chen Z, Yang J, et al. Acoustic properties of vowel production in Mandarin-speaking patients with post-stroke dysarthria[J]. Sci Rep, 2018, 8(1):14188.
Castro A M, Carmona F D, Rodrigues A M, et al. Incidence and predictors of cardiovascular events in a cohort of patients with rheumatoid arthritis[J]. Acta Reumatol Port, 2016, 41(3): 213-219.
[7]
Jimenez M C, Rexrode K M, Kotler G, et al. Association between markers of inflammation and total stroke by hypertensive status among women[J]. Am J Hypertens, 2016, 29(9): 1117-24.
[8]
Pearson M J, Mungovan S F, Smart N A. Effect of aerobic and resistance training on inflammatory markers in heart failure patients: systematic review and meta-analysis[J]. Heart Fail Rev, 2018, 23(2): 209-223.
[9]
Ren H Y, Khera A, De Lemos J A, et al. Soluble endothelial cell-selective adhesion molecule and incident cardiovascular events in a multiethnic population[J]. Am Heart J, 2017, 191(8): 55-61.
Staszewski J, Piusinska M R, Brodacki B, et al. IL-6, PF-4, sCD40 L, and homocysteine are associated with the radiological progression of cerebral small-vessel disease: a 2-year follow-up study[J]. Clin Interv Aging, 2018, 13(9): 1135-1141.
Ryan A S, Li G, Hafer M C, et al. Resistive training and molecular regulators of vascular-metabolic risk in chronic stroke[J]. J Stroke Cerebrovasc Dis, 2017, 26(5): 962-968.
[17]
Lu W J, Zeng L L, Wang Y, et al. Blood micro RNA-15a correlates with IL-6, IGF-1 and acute cerebral ischemia[J]. Curr Neurovasc Res, 2018, 15(1): 63-71.
[18]
Okamoto A, Wajima D, Tei R, et al. A case of a pituitary adenoma diagnosed as carney complex syndrome in an older female patient[J]. No Shinkei Geka, 2017, 45(3): 225-231.
[19]
Okoreeh A K, Bake S, Sohrabji F. Astrocyte-specific insulin-like growth factor-1 gene transfer in aging female rats improves stroke outcomes[J]. Glia, 2017, 65(7): 1043-1058.
[20]
Zhang G, Guo X, Chen L, et al. Interferon-gamma promotes neuronal repair by transplanted neural stem cells in ischemic rats[J]. Stem Cells Dev, 2018, 27(5): 355-366.
[21]
Towfighi A, Cheng E M, Ayala-Rivera M, et al. Randomized controlled trial of a coordinated care intervention to improve risk factor control after stroke or transient ischemic attack in the safety net: secondary stroke prevention by Uniting Community and Chronic care model teams Early to End Disparities (SUCCEED)[J]. BMC Neurol, 2017, 17(1): 24.
Buerki S E, Grandgirard D, Datta A N, et al. Inflammatory markers in pediatric stroke: an attempt to better understanding the pathophysiology[J]. Eur J Paediatr Neurol, 2016, 20(2): 252-260.
2020, Vol. 31 
