Abstract：Objective To study the therapeutic effect of recombinant human epidermal growth factor combined with silver ion dressings under vacuum sealing drainage (vacuum sealing drainage, the VSD) against diabetic foot ulcer wound. Methods A total of 129 patients with diabetic foot infection treated between September 2016 and February 2019 were selected and randomly divided into three groups, with 43 cases in each. Patients in group A were treated with silver ion dressings alone, group B was additionally given recombinant human epidermal growth factor (rhEGF), while group C received vacuum sealing drainage plus the two treatments mentioned above. Wound healing was compared between the three groups after 28 days of treatment. Results The effective rate was respectively 88.4% (38/43) in group A, 93% (40/43) in group B, and 97.7% (42/43) in group C, so the difference was statistically significant (P<0.05).The VAS of group C was significantly lower than that of group B and group A, with statistically significant difference (P<0.05).In terms of wound repair, times the dressing was changed and usage of antibiotics, group C was superior to group A and group B. Conclusions The combination of recombinant human epidermal growth factor (rhEGF) with silver ions dressing under vacuum sealing drainage (VSD), when used in the treatment of diabetic foot ulcer, can effectively promote healing and granulation, so it is worthy of clinical application.
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2020, Vol. 31 
